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Information Journal Paper

Title

Protective effect of silver nano particles against ovarian polycystic induced by morphine in rat

Pages

  229-235

Abstract

 Objective: Morphine can cause harmful effects in the ovaries. But its effect on reproductive (hypothalamus-pituitary-gonad) axis is not clearly known. Today, silver nanoparticles are widely used in healthcare products because of antimicrobial properties. These particles can pass the blood-brain barrier and change in the nitric oxide level. We studied the effect of pre-injection of Ag-NPs prior to morphine (intra-VMH) in order to investigate the protective effect on the rat’ s polycystic ovary induced of morphine. The effects were also compared with those observed in the morphine addicted animal. Materials and Methods: The rats (200-250 g) were housed under standard conditions and fed ad libitum. They were randomly divided into addicted to morphine (10-100 mg/kg, i. p., 7 days, twice daily) or receiving the drug (0. 001 to 0. 4 μ g/rat, once, intra-VMH) (AP:-1. 92), a week after stereotaxic surgery. Ag-NPs (0. 01, 0. 001 and 0. 0001 μ g/rat) were administered for once (intra-VMH) alone or prior to the morphine effective dose (0. 4 μ g/rat). Control group was given only saline. At the end, the animals’ ovaries and/or brain both histopathologically and by NADPH-diaphorase were examined. Results: All rats’ ovaries treated morphine showed polycystic features compared with the saline group (p<0. 05). The activation of the NO system in the ovaries was also evidenced by NADPH-diaphorase. However, with pre-injection of the Ag-NPs, (intra-VMH) to morphine, the number of cysts was reduced and the VMH neurons were protected. Conclusion: The Ag-NPs may inhibit the morphine-induced PCO by decreasing the level of NO in the ovary through protection of hypothalamic neurons.

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    APA: Copy

    Salami, Elham, KARAMI, MANIZHEH, JAFARYAN DEHKORDI, AMENEH, JALALI NADOUSHAN, MOHAMMADREZA, & Hajnorouzi, Abazar. (2018). Protective effect of silver nano particles against ovarian polycystic induced by morphine in rat. NANOMEDICINE RESEARCH JOURNAL, 3(4), 229-235. SID. https://sid.ir/paper/780346/en

    Vancouver: Copy

    Salami Elham, KARAMI MANIZHEH, JAFARYAN DEHKORDI AMENEH, JALALI NADOUSHAN MOHAMMADREZA, Hajnorouzi Abazar. Protective effect of silver nano particles against ovarian polycystic induced by morphine in rat. NANOMEDICINE RESEARCH JOURNAL[Internet]. 2018;3(4):229-235. Available from: https://sid.ir/paper/780346/en

    IEEE: Copy

    Elham Salami, MANIZHEH KARAMI, AMENEH JAFARYAN DEHKORDI, MOHAMMADREZA JALALI NADOUSHAN, and Abazar Hajnorouzi, “Protective effect of silver nano particles against ovarian polycystic induced by morphine in rat,” NANOMEDICINE RESEARCH JOURNAL, vol. 3, no. 4, pp. 229–235, 2018, [Online]. Available: https://sid.ir/paper/780346/en

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