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Information Journal Paper

Title

Development of New Indonesian Propolis Extract-Loaded Selfemulsifying: Characterization, Stability and Antibacterial Activity

Pages

  120-129

Abstract

 Purpose: This study aimed to prepare, characterize, examine the stability and evaluation of the antibacterial activity of Indonesian propolis extract-loaded self-emulsifying (PESE). Methods: Oil, emulsifier, and co-emulsifier were selected as the carrier for the PESE formulation through a propolis-extract solubility test on each carrier, followed by evaluation of the nanoemulsion region in a pseudo ternary phase diagram. Pre-concentrate of PESE was prepared with the addition of 150 mg/mL propolis extract followed by characterization for the transmittance, globule size, zeta potential, thermodynamic stability, robustness to dilution, and accelerated stability. The selected formulation was tested for antibacterial activity using a microdilution method. Results: The PESE characterization produced a clear nanoemulsion with a globule size ranging from 13 to 45 nm and zeta potential of less than − 38 mV. The PESE formulation with a composition of 150 mg/mL propolis extract, 20% castor oil, 40%– 70% Kolliphor EL, and 10%– 40% polyethylene glycol (PEG) 400 were thermodynamically stable. The PESE formulation with the composition of 20% castor oil, 40% Kolliphor EL, and 40% PEG 400 was the optimum formulation that passed the robustness to dilution evaluation and an accelerated stability test for 3 months. The antibacterial activity test on this formulation indicated improved activity against Escherichia coli and Staphylococcus aureus compared with that of propolis extract. Conclusion: These studies demonstrated that PESE in optimum formulation could be used as an antibacterial, particularly in E. coli and S. aureus.

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    • Cite

    APA: Copy

    Syukri, Yandi, Fitria, Annisa, Hanifah, Suci, & Idrati, Muthiah. (2021). Development of New Indonesian Propolis Extract-Loaded Selfemulsifying: Characterization, Stability and Antibacterial Activity. ADVANCED PHARMACEUTICAL BULLETIN, 11(1), 120-129. SID. https://sid.ir/paper/780376/en

    Vancouver: Copy

    Syukri Yandi, Fitria Annisa, Hanifah Suci, Idrati Muthiah. Development of New Indonesian Propolis Extract-Loaded Selfemulsifying: Characterization, Stability and Antibacterial Activity. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2021;11(1):120-129. Available from: https://sid.ir/paper/780376/en

    IEEE: Copy

    Yandi Syukri, Annisa Fitria, Suci Hanifah, and Muthiah Idrati, “Development of New Indonesian Propolis Extract-Loaded Selfemulsifying: Characterization, Stability and Antibacterial Activity,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 11, no. 1, pp. 120–129, 2021, [Online]. Available: https://sid.ir/paper/780376/en

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