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Information Journal Paper

Title

Antifungal Activity of Aureobasidin A in Combination with Fluconazole against Fluconazole-Resistant Candida albicans

Pages

  285-291

Keywords

Minimum inhibitory concentration (MIC) 

Abstract

 Background: Aureobasidin A is known as a cyclic depsipeptide antibiotic with toxic effects against yeasts such as Candida spp at low concentration. Combination therapy is used as a conventional treatment for fungal infections, especially drug-resistant cases. The current study aimed to investigate the combined effects of fluconazole and Aureobasidin A on fluconazole-resistant C. albicans isolates using broth microdilution method. Materials & Methods: Antifungal activity of Aureobasidin A (AbA) compared to fluconazole against C. albicans ATCC 76615 strain was determined using the standardized broth microdilution method according to the Clinical and Laboratory Standards Institute (CLSI, document M27-Ed4) guidelines. The checkerboard method was used to test the combined effects of Aureobasidin A and fluconazole. The synergy, indifference, and antagonism were defined based on the fractional inhibitory concentration values below 0. 5, 0. 5-4, and more than 4 μ g/mL, respectively. Findings: MIC50 and MIC90 evaluations of Aureobasidin A and fluconazole were done at concentrations of 0. 25-2 and 32-64 μ g/mL against C. glabrata isolates, respectively. The synergy between fluconazole and Aureobasidin A was observed against Candida isolate. A reduced MIC was demonstrated against C. albicans isolate when fluconazole was combined with Aureobasidin A at 4 to 0. 12 μ g/mL concentrations. Conclusion: The present study findings revealed that Aureobasidin A combined with fluconazole exhibited potent inhibitory effects against fluconazole-resistant C. albicans isolates. Further studies is recommended to investigate the synergistic effects of Aureobasidin A and other antifungal drugs.

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    Cite

    APA: Copy

    ALIMEHR, SHADI, SHAMS GHAHFAROKHI, MASOOMEH, & RAZZAGHI ABYANEH, MEHDI. (2020). Antifungal Activity of Aureobasidin A in Combination with Fluconazole against Fluconazole-Resistant Candida albicans. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), 6(4), 285-291. SID. https://sid.ir/paper/780933/en

    Vancouver: Copy

    ALIMEHR SHADI, SHAMS GHAHFAROKHI MASOOMEH, RAZZAGHI ABYANEH MEHDI. Antifungal Activity of Aureobasidin A in Combination with Fluconazole against Fluconazole-Resistant Candida albicans. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE)[Internet]. 2020;6(4):285-291. Available from: https://sid.ir/paper/780933/en

    IEEE: Copy

    SHADI ALIMEHR, MASOOMEH SHAMS GHAHFAROKHI, and MEHDI RAZZAGHI ABYANEH, “Antifungal Activity of Aureobasidin A in Combination with Fluconazole against Fluconazole-Resistant Candida albicans,” INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), vol. 6, no. 4, pp. 285–291, 2020, [Online]. Available: https://sid.ir/paper/780933/en

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