Evaluation of iron overload by cardiac and liver T2* in B-thalassemia: Correlation with serum ferritin, heart function and liver enzymes

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Khadivi Heris Hengameh; NEJATI BABAK; Rezazadeh Khatereh; SATE HOSSEIN; DOLATKHAH ROYA; GHOREISHI ZOHREH; ESFAHANI ALI

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Journal: Journal of Cardiovascular and Thoracic Research Year:2021 | Volume:13 | Issue:1 Page(s): 54-60

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Title

Evaluation of iron overload by cardiac and liver T2* in B-thalassemia: Correlation with serum ferritin, heart function and liver enzymes

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Keywords

Cardiomyopathy T2* Magnetic Resonance Imaging Ferritin Iron Overload β

Thalassemia

Abstract

Introduction: In this study, we aimed to assess the relationship of cardiac and hepatic T2* magnetic resonance imaging (MRI) values as a gold standard for detecting iron overload with serum ferritin level, heart function, and liver enzymes as alternative diagnostic methods. Methods: A total 58 patients with beta-Thalassemia major who were all transfusion dependent were evaluated for the study. T2* MRI of heart and liver, echocardiography, serum ferritin level, and liver enzymes measurement were performed. The relationship between T2* MRI findings and other assessments were examined. Cardiac and hepatic T2* findings were categorized as normal, mild, moderate, and severe iron overload. Results: 22% and 11% of the patients were suffering from severe iron overload in heart and liver, respectively. The echocardiographic findings were not significantly different among different iron load categories in heart or liver. ALT level was significantly higher in patient with severe iron overload than those with normal iron load in heart (P = 0. 005). Also, AST level was significantly lower in normal iron load group than mild, moderate, and severe iron load groups in liver (P < 0. 05). The serum ferritin level was significantly inversely correlated with cardiac T2* values (r =-0. 34, P = 0. 035) and hepatic T2* values (r =-0. 52, P = 0. 001). Conclusion: Cardiac and hepatic T2* MRI indicated significant correlation with serum ferritin level.

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APA: Copy

Khadivi Heris, Hengameh, NEJATI, BABAK, Rezazadeh, Khatereh, SATE, HOSSEIN, DOLATKHAH, ROYA, GHOREISHI, ZOHREH, & ESFAHANI, ALI. (2021). Evaluation of iron overload by cardiac and liver T2* in B-thalassemia: Correlation with serum ferritin, heart function and liver enzymes. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 13(1), 54-60. SID. https://sid.ir/paper/781034/en

Vancouver: Copy

Khadivi Heris Hengameh, NEJATI BABAK, Rezazadeh Khatereh, SATE HOSSEIN, DOLATKHAH ROYA, GHOREISHI ZOHREH, ESFAHANI ALI. Evaluation of iron overload by cardiac and liver T2* in B-thalassemia: Correlation with serum ferritin, heart function and liver enzymes. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2021;13(1):54-60. Available from: https://sid.ir/paper/781034/en

IEEE: Copy

Hengameh Khadivi Heris, BABAK NEJATI, Khatereh Rezazadeh, HOSSEIN SATE, ROYA DOLATKHAH, ZOHREH GHOREISHI, and ALI ESFAHANI, “Evaluation of iron overload by cardiac and liver T2* in B-thalassemia: Correlation with serum ferritin, heart function and liver enzymes,” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 13, no. 1, pp. 54–60, 2021, [Online]. Available: https://sid.ir/paper/781034/en

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