ANTINOCICEPTIVE EFFECTS OF ETHANOLIC EXTRACT OF SALVIA AETHIOPIS IN NMRI MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

EIDI A.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Armaghane Danesh Year:2014 | Volume:19 | Issue:1 (84) Page(s): 24-35

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

769

Download:

Cites:

Information Journal Paper

Title

ANTINOCICEPTIVE EFFECTS OF ETHANOLIC EXTRACT OF SALVIA AETHIOPIS IN NMRI MICE

Author(s)

EIDI A. | Issue Writer Certificate

Keywords

ANALGESIAQ2

MICEQ2

PAINQ2

SALVIA AETHIOPISQ2

Abstract

Background & aim: Herbal medicine has been used to relieve PAIN around the world for many years. The aim of this study was to evaluate the analgesic effect of ethanol extract on the aerial parts of SALVIA AETHIOPIS in NMRI MICE.Methods: In the present experimental study, 126 MICE (NMRI) were randomly selected and used for formalin, hot plate and acetic acid test. In every experiment there were seven groups of six MICE. The rats were administrated with SALVIA AETHIOPIS extract at concentrations of (1, 10, 50 and 100 mg/kg body wt.) or morphine at concentration of (10 mg/kg body wt.) as the standard drug.The intact animals were used as controls and the control group was treated with saline. In the formalin test, formalin was injected into the dorsal surface of the right paw. The animals were observed for 45 min after injection of formalin and PAIN scores were recorded. After formalin injection, the PAIN rated from 0 to 5 min (early phase) and 15-45 min (second phase) were counted. In hot plate test, rats were placed on an aluminum hot plate kept at a temperature of 55±0.5oC for a maximum time of 30 s. Reaction time was recorded when the animals licked their fore and hind paws and jumped at 0 and 15, 30, 45 and 60 min after intraperitoneal administration of the extract. In acetic acid experiment, the induced PAIN was counted by acetic acid administration. The number of abdominal constrictions induced by acetic acid were subsequently counted. The analgesic activity of the abdominal contractions were inhibited. The data were analysis by of one-way ANOVA test.Results: The results showed that the extract decreased only the second phase of formalin-induced PAIN (p<0.05). the extract reduced the cramps induced by acetic acid (p<0.05). In the hot plate test, the ethanolic extract was able to increase the PAIN threshold during 60 min.Conclusion: The present data indicated that this plant had an antinociceptive effect on the MICE, but more research is needed to clarify the mechanism of action of the analgesic effect of ethanolic extract of SALVIA AETHIOPIS.

Cites

No record.

References

Cite

APA: Copy

EIDI, A.. (2014). ANTINOCICEPTIVE EFFECTS OF ETHANOLIC EXTRACT OF SALVIA AETHIOPIS IN NMRI MICE. ARMAGHAN DANESH, 19(1 (84)), 24-35. SID. https://sid.ir/paper/78156/en

Vancouver: Copy

EIDI A.. ANTINOCICEPTIVE EFFECTS OF ETHANOLIC EXTRACT OF SALVIA AETHIOPIS IN NMRI MICE. ARMAGHAN DANESH[Internet]. 2014;19(1 (84)):24-35. Available from: https://sid.ir/paper/78156/en

IEEE: Copy

A. EIDI, “ANTINOCICEPTIVE EFFECTS OF ETHANOLIC EXTRACT OF SALVIA AETHIOPIS IN NMRI MICE,” ARMAGHAN DANESH, vol. 19, no. 1 (84), pp. 24–35, 2014, [Online]. Available: https://sid.ir/paper/78156/en

Related Journal Papers