Effect of Eight Weeks of Aerobic Exercise before Cerebral Ischemia on Expression of NT-3 and TrkC in Male Rats

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Yazdanian Mohtaram; MOAZZAMI MAHTAB; SHABANI MOHAMMAD; CHERAGH BIRJANDI SADEGH

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Journal Paper

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Journal: MEDICAL LABORATORY JOURNAL Year:2020 | Volume:14 | Issue:5 Page(s): 35-41

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Title

Effect of Eight Weeks of Aerobic Exercise before Cerebral Ischemia on Expression of NT-3 and TrkC in Male Rats

Author(s)

Yazdanian Mohtaram | MOAZZAMI MAHTAB | SHABANI MOHAMMAD | CHERAGH BIRJANDI SADEGH | Issue Writer Certificate

Keywords

Exercise Preconditioning

Ischemia/Reperfusion

NT-3

TrkC

Cell death

Abstract

Background and objectives: Cerebral ischemia causes irreversible structural and functional damage in certain areas of the brain, especially the hippocampus. Evidence indicates that physical exercise may reduce the damages caused by cerebral ischemia. The purpose of this study was to examine effects of eight weeks of Exercise Preconditioning on the expression of neurotrophin-3 (NT-3) and tyrosine kinase receptor C (TrkC) in the CA1 region of the hippocampus after cerebral ischemicreperfusion in male rats. Methods: Twenty one male Wistar rats weighing 250-300 g were randomly selected and divided into three groups (healthy control, control+ischemia and exercise+ischemia). Rats in the exercise group ran on a treadmill, five days per week for eight weeks. Ischemia was induced by occlusion of both common carotid arteries for 45 minutes. In order to evaluate gene expression, real-time PCR was performed. Results: The expression of NT-3 gene was significantly higher in the exercise+ischemia and control+ischemia groups than in the healthy control group (P<0. 05). Moreover, TrkC gene expression was significantly lower in the exercise+ischemia and control+ischemia groups than in the healthy control group (P<0. 05). Conclusion: Exercise before the induction of ischemic stroke increases NT-3 expression but does not influence TrkC expression.

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APA: Copy

Yazdanian, Mohtaram, MOAZZAMI, MAHTAB, SHABANI, MOHAMMAD, & CHERAGH BIRJANDI, SADEGH. (2020). Effect of Eight Weeks of Aerobic Exercise before Cerebral Ischemia on Expression of NT-3 and TrkC in Male Rats. MEDICAL LABORATORY JOURNAL, 14(5), 35-41. SID. https://sid.ir/paper/782146/en

Vancouver: Copy

Yazdanian Mohtaram, MOAZZAMI MAHTAB, SHABANI MOHAMMAD, CHERAGH BIRJANDI SADEGH. Effect of Eight Weeks of Aerobic Exercise before Cerebral Ischemia on Expression of NT-3 and TrkC in Male Rats. MEDICAL LABORATORY JOURNAL[Internet]. 2020;14(5):35-41. Available from: https://sid.ir/paper/782146/en

IEEE: Copy

Mohtaram Yazdanian, MAHTAB MOAZZAMI, MOHAMMAD SHABANI, and SADEGH CHERAGH BIRJANDI, “Effect of Eight Weeks of Aerobic Exercise before Cerebral Ischemia on Expression of NT-3 and TrkC in Male Rats,” MEDICAL LABORATORY JOURNAL, vol. 14, no. 5, pp. 35–41, 2020, [Online]. Available: https://sid.ir/paper/782146/en

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