In Vitro Assessment of Magnetic Liposomal Paclitaxel Nanoparticles as a Potential Carrier for the Treatment of Ovarian Cancer

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YOUSEFI ALDASHI SARA; SAFFARI ZAHRA; EBRAHIMI SHAHMABADI HASAN; AKBARZADEH AZIM

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Journal Paper

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Journal: Advanced Pharmaceutical Bulletin Year:2021 | Volume:11 | Issue:2 Page(s): 267-273

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Title

In Vitro Assessment of Magnetic Liposomal Paclitaxel Nanoparticles as a Potential Carrier for the Treatment of Ovarian Cancer

Author(s)

YOUSEFI ALDASHI SARA | SAFFARI ZAHRA | EBRAHIMI SHAHMABADI HASAN | AKBARZADEH AZIM | Issue Writer Certificate

Keywords

Cytotoxicity

Drug delivery

Magnetic liposome

Nanoparticles

Ovarian cancer

Paclitaxel

Abstract

Purpose: This study aimed to evaluate the role of Magnetic liposome Nanoparticles (ML NPs) as a carrier for Paclitaxel (PTX) for the treatment of Ovarian cancer in vitro. Methods: Magnetic NPs (MNPs) were synthesized by chemical co-precipitation method. The resulting NPs were characterized in terms of size, size distribution, zeta potential, drug encapsulation efficiency (EE), drug release pattern, and Cytotoxicity effects. Results: The size and zeta potential of PTX-PEG-L and PTX-PEG-ML NPs were determined to be 296, 198 nm;-20, and-19 mV, respectively. Also, their drug encapsulation efficiencies were determined to be 97% and 96%, respectively. It was found that PTX-PEG-ML NPs, compared to PTX-PEG-L NPs, caused a reduction (11%) in the rate of drug release. The Cytotoxicity of the drug-loaded NPs was assessed using 3-[4, 5-dimethylthiazole-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay against human ovarian epithelial cancer (A2780CP) cells, and the results demonstrated that PTX-PEG-ML NPs caused higher Cytotoxicity (by 14%) compared to PTXPEG-L NPs (IC50: 1. 88 ± 0. 09 and 2. 142 ± 0. 1 μ M, respectively). Conclusion: Overall, the results of this study suggest that PTX-PEG-ML NPs could be considered as a therapeutic candidate for the treatment of Ovarian cancer.

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APA: Copy

YOUSEFI ALDASHI, SARA, SAFFARI, ZAHRA, EBRAHIMI SHAHMABADI, HASAN, & AKBARZADEH, AZIM. (2021). In Vitro Assessment of Magnetic Liposomal Paclitaxel Nanoparticles as a Potential Carrier for the Treatment of Ovarian Cancer. ADVANCED PHARMACEUTICAL BULLETIN, 11(2), 267-273. SID. https://sid.ir/paper/783756/en

Vancouver: Copy

YOUSEFI ALDASHI SARA, SAFFARI ZAHRA, EBRAHIMI SHAHMABADI HASAN, AKBARZADEH AZIM. In Vitro Assessment of Magnetic Liposomal Paclitaxel Nanoparticles as a Potential Carrier for the Treatment of Ovarian Cancer. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2021;11(2):267-273. Available from: https://sid.ir/paper/783756/en

IEEE: Copy

SARA YOUSEFI ALDASHI, ZAHRA SAFFARI, HASAN EBRAHIMI SHAHMABADI, and AZIM AKBARZADEH, “In Vitro Assessment of Magnetic Liposomal Paclitaxel Nanoparticles as a Potential Carrier for the Treatment of Ovarian Cancer,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 11, no. 2, pp. 267–273, 2021, [Online]. Available: https://sid.ir/paper/783756/en

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