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Title

Effect of Recombinant Insulin-like Growth Factor-2 Injected into the Hippocampus on Memory Impairment Following Hippocampal Intracerebral Hemorrhage in Rats

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Abstract

 Background: Insulin-like growth factor 2 (IGF-2) is a growth factor and an anti-infl ammatory cytokine that plays a pivotal role in Memory. In this study, we examined the effect of recombinant IGF-2 on Memory impairment due to Intracerebral Hemorrhage (ICH). Avoidance and recognition Memory, locomotor activity, neurological deficit score (NDS), and the level of the IGF-2 gene expression were evaluated. Materials and Methods: To induce ICH, 100 μ L of autologous blood was injected into the left Hippocampus of male Sprague Dawley rats. Recombinant IGF-2 was injected into the damaged Hippocampus 30 minutes after the induction of ICH. Then, over two weeks, NDS, locomotor activity, passive avoidance, and novel object recognition (NOR) test were evaluated. Finally, the level of IGF-2 gene expression was evaluated by using the real-time polymerase chain reaction technique. Result: Our results indicated that recombinant IGF-2 injection significantly increased step-through latency (P<0. 001) and total time spent in the dark box (P<0. 01). However, no significant difference was seen in recognition Memory and NDS. Locomotor activity did not significantly change in any group. A significantly reduced level of IGF-2 was observed after two weeks (P<0. 05). Conclusion: The results of this study show that a single dose of recombinant IGF-2 injection can infl uence Hippocampus-dependent memories. Importantly, IGF-2 did not change locomotor activity and NDS after two weeks, which probably represents its specific function in Memory.

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    APA: Copy

    VAFAEE, FARZANEH, Zarifkar, Asadollah, EMAMGHOREISHI, MASOUMEH, NAMAVAR, MOHAMMAD REZA, Shahpari, Marzieh, & ZARIFKAR, AMIR HOSSEIN. (2018). Effect of Recombinant Insulin-like Growth Factor-2 Injected into the Hippocampus on Memory Impairment Following Hippocampal Intracerebral Hemorrhage in Rats. GALEN MEDICAL JOURNAL, 7(1), 0-0. SID. https://sid.ir/paper/784017/en

    Vancouver: Copy

    VAFAEE FARZANEH, Zarifkar Asadollah, EMAMGHOREISHI MASOUMEH, NAMAVAR MOHAMMAD REZA, Shahpari Marzieh, ZARIFKAR AMIR HOSSEIN. Effect of Recombinant Insulin-like Growth Factor-2 Injected into the Hippocampus on Memory Impairment Following Hippocampal Intracerebral Hemorrhage in Rats. GALEN MEDICAL JOURNAL[Internet]. 2018;7(1):0-0. Available from: https://sid.ir/paper/784017/en

    IEEE: Copy

    FARZANEH VAFAEE, Asadollah Zarifkar, MASOUMEH EMAMGHOREISHI, MOHAMMAD REZA NAMAVAR, Marzieh Shahpari, and AMIR HOSSEIN ZARIFKAR, “Effect of Recombinant Insulin-like Growth Factor-2 Injected into the Hippocampus on Memory Impairment Following Hippocampal Intracerebral Hemorrhage in Rats,” GALEN MEDICAL JOURNAL, vol. 7, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/784017/en

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