Association Study of the Beta-Adrenergic Receptor Genetic Variant Gly389Arg and Fluoxetine Response in Major Depression

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Firouzabadi Negar; Asadpour Roja; Zomorrodian Kamiar

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Journal Paper

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Journal: Galen Medical Journal Year:2020 | Volume:9 | Issue:1 Page(s): 0-0

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Title

Association Study of the Beta-Adrenergic Receptor Genetic Variant Gly389Arg and Fluoxetine Response in Major Depression

Author(s)

Firouzabadi Negar | Asadpour Roja | Zomorrodian Kamiar | Issue Writer Certificate

Keywords

Major Depressive Disorder

Fluoxetine

Genetic Polymorphism

Pharmacogenetics

Abstract

Background: Pharmacogenetics has proven role in the treatment of different illnesses. Patients with special genotypes may achieve a better response to a specific drug. On the other hand, genetic parameters markedly contribute to the development of Major Depressive Disorder (MDD). The significance of adrenergic system compartments in cognition and behavior, and their role in etiology of depression denote that adrenergic receptors beta gene polymorphism(s) might also have an association with drug response. Thus this study aims to evaluate the association between β 1AR gene polymorphisms, G1165C, Arg389Gly and response to Fluoxetine in MDD patients. Materials and Methods: Among different antidepressants, we focused on Fluoxetine as it is prescribed frequently in MDD and belongs to one of the most efficient antidepressant categories with minimum side effects. MDD was diagnosed at study entry using DSM-IV criteria. One hundred and one new MDD patients were treated with Fluoxetine for a period of 6 weeks. A 50% decrease in Hamilton Rating Scale for Depression (HRSD) was considered as response to treatment. Genotyping of G1165C polymorphism was performed by PCR-RFLP method. Results: Results of the study indicated no significant relationship between β 1AR polymorphism and the patient’ s response to Fluoxetine neither at genotypic nor allelic level (P=0. 568). Conclusion: Our study did not support the hypothesis of involvement of β 1AR Arg389Gly polymorphism and response to Fluoxetine in MDD patients.

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APA: Copy

Firouzabadi, Negar, Asadpour, Roja, & Zomorrodian, Kamiar. (2020). Association Study of the Beta-Adrenergic Receptor Genetic Variant Gly389Arg and Fluoxetine Response in Major Depression. GALEN MEDICAL JOURNAL, 9(1), 0-0. SID. https://sid.ir/paper/784038/en

Vancouver: Copy

Firouzabadi Negar, Asadpour Roja, Zomorrodian Kamiar. Association Study of the Beta-Adrenergic Receptor Genetic Variant Gly389Arg and Fluoxetine Response in Major Depression. GALEN MEDICAL JOURNAL[Internet]. 2020;9(1):0-0. Available from: https://sid.ir/paper/784038/en

IEEE: Copy

Negar Firouzabadi, Roja Asadpour, and Kamiar Zomorrodian, “Association Study of the Beta-Adrenergic Receptor Genetic Variant Gly389Arg and Fluoxetine Response in Major Depression,” GALEN MEDICAL JOURNAL, vol. 9, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/784038/en

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