Rivaroxaban Experience at Tertiary Care Centre in Saudi Arabia: A Retrospective Observational Study

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Riazuddin Muhammad; Mpharm Mohamed Ahmed; Butt Muhammad Imran; Abufarhaneh Mohammed; Khan Shahid Masud; Emadi Omar; AlKasab Mohammed Saad; Alsudairy Haifa Fahad; AlShammari Khalid; Sheikh Aamir; AlRashed Abdulaziz

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Journal: Galen Medical Journal Year:2020 | Volume:9 | Issue:1 Page(s): 0-0

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Title

Rivaroxaban Experience at Tertiary Care Centre in Saudi Arabia: A Retrospective Observational Study

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Keywords

Anticoagulants

Atrial Fibrillation

Rivaroxaban

Stroke

Thromboembolism

Abstract

Background: Atrial Fibrillation (AF) and Venous Thromboembolism (VTE) are significant causes of morbidity and mortality. Direct oral Anticoagulants (DOACs) are as effective as vitamin K antagonists (VKAs) with a propensity to cause less major bleeding. This study aimed to assess the safety and effectiveness of Rivaroxaban in routine clinical practice in a large tertiary referral center in Saudi Arabia. Methods and Materials: In this study, patients who received Rivaroxaban at a tertiary referral hospital were included in this study. All adverse events were recorded, including major bleeding, non-major bleeding events, symptomatic thromboembolic events (deep vein thrombosis, pulmonary embolism) and all-cause death. Results: A total of 509 patients were prescribed Rivaroxaban during the study period. The most common indication for Rivaroxaban was non-valvular AF (65. 3%) and VTE (34. 7%). The mean age was 60. 4 ± 16. 4 years, and 50. 8% were female. The median CHA2DS2-Vasc score was 2. 1 in patients on Rivaroxaban for non-valvular AF. Bleeding occurred in 72 (14. 1%) patients, of which 20 (3. 9%) had major bleeds. Thrombosis events occurred in 13 (2. 5%) patients in the overall cohort. Fourteen (2. 7%) patients died during the study, including a case of fatal bleeding secondary to Rivaroxaban. Conclusion: This study describes the use of Rivaroxaban in a broad patient population in clinical practice in the Middle East. The overall bleeding and thrombosis rates in this study were comparable to those seen in major clinical trials.

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APA: Copy

Riazuddin, Muhammad, Mpharm, Mohamed Ahmed, Butt, Muhammad Imran, Abufarhaneh, Mohammed, Khan, Shahid Masud, Emadi, Omar, AlKasab, Mohammed Saad, Alsudairy, Haifa Fahad, AlShammari, Khalid, Sheikh, Aamir, & AlRashed, Abdulaziz. (2020). Rivaroxaban Experience at Tertiary Care Centre in Saudi Arabia: A Retrospective Observational Study. GALEN MEDICAL JOURNAL, 9(1), 0-0. SID. https://sid.ir/paper/784057/en

Vancouver: Copy

Riazuddin Muhammad, Mpharm Mohamed Ahmed, Butt Muhammad Imran, Abufarhaneh Mohammed, Khan Shahid Masud, Emadi Omar, AlKasab Mohammed Saad, Alsudairy Haifa Fahad, AlShammari Khalid, Sheikh Aamir, AlRashed Abdulaziz. Rivaroxaban Experience at Tertiary Care Centre in Saudi Arabia: A Retrospective Observational Study. GALEN MEDICAL JOURNAL[Internet]. 2020;9(1):0-0. Available from: https://sid.ir/paper/784057/en

IEEE: Copy

Muhammad Riazuddin, Mohamed Ahmed Mpharm, Muhammad Imran Butt, Mohammed Abufarhaneh, Shahid Masud Khan, Omar Emadi, Mohammed Saad AlKasab, Haifa Fahad Alsudairy, Khalid AlShammari, Aamir Sheikh, and Abdulaziz AlRashed, “Rivaroxaban Experience at Tertiary Care Centre in Saudi Arabia: A Retrospective Observational Study,” GALEN MEDICAL JOURNAL, vol. 9, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/784057/en

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