مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

377
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

48
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Methadone Toxicity with Electrocardiographic Sodium Channel Blockade Changes in a Pediatric Patient Post-cardiopulmonary Arrest: a Case Report

Pages

  29-32

Abstract

 Background: Cardiopulmonary arrest in the pediatric population due to methadone toxicity is not commonly reported. Severe methadone toxicity often involves respiratory depression with reports of orthostatic hypotension, due to vasodilation, and QTc prolongation. Case presentation: A pair of toddler siblings presented in cardiopulmonary arrest due to methadone ingestion. They were successfully resuscitated with no significant neurobehavioral deficits despite a suspected prolonged “ downtime. ” After return of spontaneous circulation, the older sibling, a four-year old male, had electrocardiographs (ECGs) that were suggestive of sodium channel blockade. These changes were reversed following bicarbonate therapy. The two-year old child’ s ECGs did not show such changes. Discussion: There is no prior clinical literature on sodium channel blockade in methadone toxicity. The older sibling’ s ECG findings and response to bicarbonate therapy appeared to be consistent with sodium channel blockade. There have been preclinical data that suggest methadone cardiotoxicity may involve cardiac sodium channels. Pharmacogenetic variations could also explain how these effects may selectively manifest. Conclusion: Physicians should be aware of the possible toxicologic causes of cardiopulmonary arrest in the pediatric population. Pharmacogenetic variations may contribute to different clinical manifestations in methadone cardiotoxicity.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    KWANG ONG, GENE YONG. (2020). Methadone Toxicity with Electrocardiographic Sodium Channel Blockade Changes in a Pediatric Patient Post-cardiopulmonary Arrest: a Case Report. ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT), 9(1), 29-32. SID. https://sid.ir/paper/784199/en

    Vancouver: Copy

    KWANG ONG GENE YONG. Methadone Toxicity with Electrocardiographic Sodium Channel Blockade Changes in a Pediatric Patient Post-cardiopulmonary Arrest: a Case Report. ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT)[Internet]. 2020;9(1):29-32. Available from: https://sid.ir/paper/784199/en

    IEEE: Copy

    GENE YONG KWANG ONG, “Methadone Toxicity with Electrocardiographic Sodium Channel Blockade Changes in a Pediatric Patient Post-cardiopulmonary Arrest: a Case Report,” ASIA PACIFIC JOURNAL OF MEDICAL TOXICOLOGY (APJMT), vol. 9, no. 1, pp. 29–32, 2020, [Online]. Available: https://sid.ir/paper/784199/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button