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Information Journal Paper

Title

Preparation, Statistical Optimization and Characterization of Propolis-Loaded Solid Lipid Nanoparticles Using Box-Behnken Design

Pages

  301-310

Abstract

 Purpose: Propolis is a resinous material obtained by honeybees with many biological and pharmacological properties which can be used for treatment of various diseases. Current study aims to formulate and characterize Propolis-loaded solid lipid nanoparticles (SLNs) carrier system. Methods: The prepared SLNs, composed of glyceryl monostearate (GMS), Soy lecithin, Tween 80 and polyethylene glycol 400 (PEG 400), were fabricated employing solvent emulsificationevaporation technique. In addition, the impact of several variables including concentration ratios of GMS/Soy lecithin and PEG 400/Tween 80 along with emulsification time were evaluated on the size, polydispersity index (PDI) and zeta potential of particles. SLN formulations were optimized using Box-Behnken design. The particles were freeze dried and morphologically studied by scanning electron microscopy (SEM). The in-vitro release profile of Propolis entrapped in the optimized nanoparticles was investigated. Results: The mean particle size, PDI, zeta potential, entrapment efficiency (EE) and loading efficiency (LE) of optimized Propolis-loaded SLNs were found to be 122. 6± 22. 36 nm, 0. 28± 0. 06,-26. 18± 3. 3 mV, 73. 57± 0. 86% and 3. 29± 0. 27%, respectively. SEM images exhibited nanoparticles to be non-aggregated and in spherical shape. The in-vitro release study showed prolonged release of Propolis from nanoparticles. Conclusion: The results implied that the proposed way of SLN preparation could be considered as a proper method for production of Propolis loaded colloidal carrier system.

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    APA: Copy

    Taherzadeh, Sahar, Naeimifar, Atefeh, Mehrabani Yeganeh, Ehsan, ESMAILI, ZAHRA, MAHJUB, REZA, & AKBARI JAVAR, HAMID. (2021). Preparation, Statistical Optimization and Characterization of Propolis-Loaded Solid Lipid Nanoparticles Using Box-Behnken Design. ADVANCED PHARMACEUTICAL BULLETIN, 11(2), 301-310. SID. https://sid.ir/paper/784262/en

    Vancouver: Copy

    Taherzadeh Sahar, Naeimifar Atefeh, Mehrabani Yeganeh Ehsan, ESMAILI ZAHRA, MAHJUB REZA, AKBARI JAVAR HAMID. Preparation, Statistical Optimization and Characterization of Propolis-Loaded Solid Lipid Nanoparticles Using Box-Behnken Design. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2021;11(2):301-310. Available from: https://sid.ir/paper/784262/en

    IEEE: Copy

    Sahar Taherzadeh, Atefeh Naeimifar, Ehsan Mehrabani Yeganeh, ZAHRA ESMAILI, REZA MAHJUB, and HAMID AKBARI JAVAR, “Preparation, Statistical Optimization and Characterization of Propolis-Loaded Solid Lipid Nanoparticles Using Box-Behnken Design,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 11, no. 2, pp. 301–310, 2021, [Online]. Available: https://sid.ir/paper/784262/en

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