MOLECULAR EVALUATION OF HUMAN NEUTROPHILANTIGEN (HNA-3) IN SOME BLOOD DONORS

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SHAHIN F.; SHAIEGAN M.; SAMIEE SH.; BAYAT B.; NADALI F.; ATAIE Z.; SAYYADI M.; CHEGINI A.

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Journal: The Scientific Journal of Iranian Blood Transfusion Year:2016 | Volume:13 | Issue:3 Page(s): 176-184

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Title

MOLECULAR EVALUATION OF HUMAN NEUTROPHILANTIGEN (HNA-3) IN SOME BLOOD DONORS

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Keywords

HNA-3A ANTIGENQ2

HUMANQ2

BLOOD DONORSQ2

EDTAQ2

Abstract

Background and Objectives: Neutrophil alloantigens are involved in several blood transfusion reactions including transfusion related acute lung injury (TRALI), refractoriness to granulocyte transfusions and febrile transfusion reactions (FNHTRs). Due to lack of reports on neutrophil antigens, we aimed to detect the frequency rates of HNA-3a and HNA-3b antigens in some BLOOD DONORS living in Tehran.Materials and Methods: Blood samples were collected in EDTA (anticoagulant) containing tubes from 110 BLOOD DONORS having referred to Tehran Blood Center. DNA was extracted by silica filtered columns. PCR-SSP was used for evaluation of HNA-3a, HNA-3b. The gene frequency rates of HNA 3a and HNA-3b antigenes were calculated by Hardy Weinberg equilibrium.Results: The gene frequencies of HNA-3a, HNA-3b were 0.74 and 0.26, respectively showing consistency with the Hardy-Weinberg equilibrium. HNA-3a phenotypic frequency was found in 103 (93.6%) BLOOD DONORS while 7 (6.4%) showed lacking it. HNA-3b was found in 50 (45.5%) BLOOD DONORS while 60 (54.5%) lacking. There was not found any differences in gene and antigene frequency rates between the two genders.Conclusions: The frequencies of HNA-3a and -3b were similar to those found in the previous study conducted on German and Turkish populations.

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APA: Copy

SHAHIN, F., SHAIEGAN, M., SAMIEE, SH., BAYAT, B., NADALI, F., ATAIE, Z., SAYYADI, M., & CHEGINI, A.. (2016). MOLECULAR EVALUATION OF HUMAN NEUTROPHILANTIGEN (HNA-3) IN SOME BLOOD DONORS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 13(3), 176-184. SID. https://sid.ir/paper/78430/en

Vancouver: Copy

SHAHIN F., SHAIEGAN M., SAMIEE SH., BAYAT B., NADALI F., ATAIE Z., SAYYADI M., CHEGINI A.. MOLECULAR EVALUATION OF HUMAN NEUTROPHILANTIGEN (HNA-3) IN SOME BLOOD DONORS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2016;13(3):176-184. Available from: https://sid.ir/paper/78430/en

IEEE: Copy

F. SHAHIN, M. SHAIEGAN, SH. SAMIEE, B. BAYAT, F. NADALI, Z. ATAIE, M. SAYYADI, and A. CHEGINI, “MOLECULAR EVALUATION OF HUMAN NEUTROPHILANTIGEN (HNA-3) IN SOME BLOOD DONORS,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 13, no. 3, pp. 176–184, 2016, [Online]. Available: https://sid.ir/paper/78430/en

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