مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Preparation, Physicochemical Characterization and Anti-Fungal Evaluation of Amphotericin B-Loaded PLGA-PEG-Galactosamine Nanoparticles

Pages

  311-317

Abstract

 Purpose: The present study aimed to formulate PLGA and PLGA-PEG-Galactosamine Nanoparticles (NPs) loaded with Amphotericin B with appropriate physicochemical properties and antifungal activity. PLGA was functionalized with GalN to increase the adhesion and antifungal activity of NPs against Candida albicans. Methods: The physicochemical properties of NPs were characterized by particle size determination, zeta potential, drug crystallinity, loading efficiency, dissolution studies, differential scanning calorimeter (DSC), X-ray powder diffraction (XRPD), and Fourier transform infrared (FT-IR). Antifungal activity of the NPs at different drug/polymer ratios was examined by determining minimum inhibitory concentrations (MICs). Results: the FT-IR and 1HNMR analysis successfully confirmed the formation of PLGA-PEGGalN NPs. The PLGA NPs were in the size range of 174. 1 ± 3. 49 to 238. 2± 7. 59 nm while PLGAGalN NPs were 255. 6 ± 4. 08 nm in size, respectively. Loading efficiency was in the range of 67%± 2. 4 to 77%± 1. 6, and entrapment efficiency in the range of 68. 185%± 1. 9 to 73. 05%± 0. 6. Zeta potential and loading efficiency for PLGA-GalN NPs were – 0. 456, 71%. The NPs indicated an amorphous status according to XRPD patterns and DSC thermograms. The PLGA-PEG-GalN NPs showed higher fungistatic activity than PLGA NPs. Conclusion: the results demonstrated that the antifungal activity of PLGA-PEG-GalN NPs was higher than pure Amphotericin B and PLGA NPs.

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    APA: Copy

    MOHAMMADI, GHOBAD, Fathian Kolahkaj, Mostafa, Mohammadi, Pardis, ADIBKIA, KHOSRO, & fattahi, ali. (2021). Preparation, Physicochemical Characterization and Anti-Fungal Evaluation of Amphotericin B-Loaded PLGA-PEG-Galactosamine Nanoparticles. ADVANCED PHARMACEUTICAL BULLETIN, 11(2), 311-317. SID. https://sid.ir/paper/784628/en

    Vancouver: Copy

    MOHAMMADI GHOBAD, Fathian Kolahkaj Mostafa, Mohammadi Pardis, ADIBKIA KHOSRO, fattahi ali. Preparation, Physicochemical Characterization and Anti-Fungal Evaluation of Amphotericin B-Loaded PLGA-PEG-Galactosamine Nanoparticles. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2021;11(2):311-317. Available from: https://sid.ir/paper/784628/en

    IEEE: Copy

    GHOBAD MOHAMMADI, Mostafa Fathian Kolahkaj, Pardis Mohammadi, KHOSRO ADIBKIA, and ali fattahi, “Preparation, Physicochemical Characterization and Anti-Fungal Evaluation of Amphotericin B-Loaded PLGA-PEG-Galactosamine Nanoparticles,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 11, no. 2, pp. 311–317, 2021, [Online]. Available: https://sid.ir/paper/784628/en

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