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Information Journal Paper

Title

The Effect of Vitamin D Deficiency on Overgrowth of Uterine Fibroids: A Blinded Randomized Clinical Trial

Pages

  95-100

Abstract

 Background: To evaluate the effects of Vitamin D (vitD) supplement on uterine fibroid growth. Materials and Methods: A randomized blinded clinical trial was conducted at a tertiary university-based hospital from August 2017 to September 2018. Totally, 204 women were enrolled into the study. They had at least one uterine fibroid >10 mm on transvaginal ultrasound and their vitD level was insufficient (i. e. 20-30 ng/ml). The intervention group was treated with vitD 50000 U supplements for two months. After 2 months, ultrasound screening and vitD level measurement was done in both groups. Results: At first, the mean serum vitD levels in intervention and control group were 23. 62 and 23. 20 ng/ml, respec-tively. After 8 weeks, the mean serum vitD levels in the control and intervention group were 22. 72 and 28. 56 ng/ml respectively (P<0. 05). Also, mean fibroma diameter in the intervention group before and after 8 weeks of vitD supplementation was 43 ± 4. 68 and 42. 6 ± 1. 31 mm, respectively. Mean uterine fibroid diameter in the control group which did not receive vitD supplements, before and after 8 weeks was 41. 98 ± 5. 25 and 47. 81 ± 3. 42 mm, respectively. The variation in the mean size of the uterine fibroid between the control and intervention group which was respectively about 5. 83 mm increase and 0. 48 mm decrease, was significant (P<0. 001). Conclusion: Our results showed that vitD supplementation prevents fibroid growth. It seems that vitD supplement is a simple, safe and inexpensive modality for Leiomyoma growth prevention (Registration number: IRCT201703122576N15).

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    Cite

    APA: Copy

    DAVARI TANHA, FATEMEH, Feizabad, Elham, VASHEGHANI FARAHANI, MARYAM, Amuzegar, Hoora, MORADI, BEHNAZ, & Samimi Sadeh, Saghar. (2021). The Effect of Vitamin D Deficiency on Overgrowth of Uterine Fibroids: A Blinded Randomized Clinical Trial. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 15(2), 95-100. SID. https://sid.ir/paper/785030/en

    Vancouver: Copy

    DAVARI TANHA FATEMEH, Feizabad Elham, VASHEGHANI FARAHANI MARYAM, Amuzegar Hoora, MORADI BEHNAZ, Samimi Sadeh Saghar. The Effect of Vitamin D Deficiency on Overgrowth of Uterine Fibroids: A Blinded Randomized Clinical Trial. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2021;15(2):95-100. Available from: https://sid.ir/paper/785030/en

    IEEE: Copy

    FATEMEH DAVARI TANHA, Elham Feizabad, MARYAM VASHEGHANI FARAHANI, Hoora Amuzegar, BEHNAZ MORADI, and Saghar Samimi Sadeh, “The Effect of Vitamin D Deficiency on Overgrowth of Uterine Fibroids: A Blinded Randomized Clinical Trial,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 15, no. 2, pp. 95–100, 2021, [Online]. Available: https://sid.ir/paper/785030/en

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