CEREBRAL VENOUS THROMBOSIS IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIA AND G20210A MUTATION OF PROTHROMBINE GENE DURING TREATMENT

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ESHGHI P.; ASNAFI AMIN

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Journal Paper

Paper Information

Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2011 | Volume:8 | Issue:2 (31) Page(s): 143-148

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Title

CEREBRAL VENOUS THROMBOSIS IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIA AND G20210A MUTATION OF PROTHROMBINE GENE DURING TREATMENT

Author(s)

ESHGHI P. | ASNAFI AMIN | Issue Writer Certificate

Keywords

LEUKEMIAQ3

VENOUS THROMBOSISQ3

MUTATIONQ3

PROTHROMBINQ3

Abstract

Background and Objectives: Cerebral vein thrombosis is a relatively rare but important complication during treatment of Acute Lymphoblastic LEUKEMIA (ALL) in children.Case: A 12 year old boy with pre-B ALL during the consolidation phase of treatment with BFM protocol was admitted with severe headache; imaging study showed cerebral VENOUS THROMBOSIS in left sigmoid and lateral sinuses. Diagnostic evaluation revealed heterozygot MUTATION in G20210A prothombin gene.Conclusions: Some hereditary hypercoagulability states such as PROTHROMBIN G20210A heterogeneity, play an important role in childhood thrombotic events during treatment of hematologic malignancy with medications such as L-asparginase. So VENOUS THROMBOSIS prophylaxis in this situation should be considered.

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APA: Copy

ESHGHI, P., & ASNAFI, AMIN. (2011). CEREBRAL VENOUS THROMBOSIS IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIA AND G20210A MUTATION OF PROTHROMBINE GENE DURING TREATMENT. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 8(2 (31)), 143-148. SID. https://sid.ir/paper/78507/en

Vancouver: Copy

ESHGHI P., ASNAFI AMIN. CEREBRAL VENOUS THROMBOSIS IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIA AND G20210A MUTATION OF PROTHROMBINE GENE DURING TREATMENT. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2011;8(2 (31)):143-148. Available from: https://sid.ir/paper/78507/en

IEEE: Copy

P. ESHGHI, and AMIN ASNAFI, “CEREBRAL VENOUS THROMBOSIS IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIA AND G20210A MUTATION OF PROTHROMBINE GENE DURING TREATMENT,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 8, no. 2 (31), pp. 143–148, 2011, [Online]. Available: https://sid.ir/paper/78507/en

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