THE PREVALENCE OF G20210A GENE MUTATIONAS IN THROMBOTIC PATIENTS

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MOGHADASI M.H.; SAMIEI SH.; AMINI KAFIABAD S.; ATAEI ZAHRA; KAVARI M.; SOBHANI MARYAM

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Journal: The Scientific Journal of Iranian Blood Transfusion Year:2008 | Volume:5 | Issue:2 (19) Page(s): 67-72

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Title

THE PREVALENCE OF G20210A GENE MUTATIONAS IN THROMBOTIC PATIENTS

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Keywords

PROTHROMBINQ3

MUTATIONQ3

PCRQ4

VENOUS THROMBOEMBOLISMQ4

Abstract

Background and Objectives: Thrombophilia is a common and dangerous disease. It may be heritable or acquired. A substitution in the 3' untranslated region of PROTHROMBIN gene (PRT-G20210A) has been reported to be related to thrombophilia in Caucasians, but this relationship remains in debate in other populations. The hetrozygote form of PRT G20210A gene variant expresses PROTHROMBIN 25% higher than the average level. This study was performed to evaluate the prevalence of G20210A gene MUTATIONas in thrombotic patients.Materials and Methods: In this descriptive and cross sectional study, 299 patients with VENOUS THROMBOEMBOLISM were selected. The subjects consisted of 116 male and 183 female. Traditional risk factors for venous thrombosis and pulmonary thromboembolism such as proteins C, S, ATIII deficiency and APC-resistance were investigated as well.Results: We found that only 1.7% of patients with VENOUS THROMBOEMBOLISM were carrier of PROTHROMBIN G20210A MUTATION which is one of the prevalent point MUTATIONs in Caucasians patients (18%). The homozygote form of PRT G20210A was not found.Conclusions: PROTHROMBIN G20210A MUTATIONs in Iranian population as opposed to western populations are rare (1.7%) with APC-resistance being common in the former.

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APA: Copy

MOGHADASI, M.H., SAMIEI, SH., AMINI KAFIABAD, S., ATAEI, ZAHRA, KAVARI, M., & SOBHANI, MARYAM. (2008). THE PREVALENCE OF G20210A GENE MUTATIONAS IN THROMBOTIC PATIENTS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 5(2 (19)), 67-72. SID. https://sid.ir/paper/78542/en

Vancouver: Copy

MOGHADASI M.H., SAMIEI SH., AMINI KAFIABAD S., ATAEI ZAHRA, KAVARI M., SOBHANI MARYAM. THE PREVALENCE OF G20210A GENE MUTATIONAS IN THROMBOTIC PATIENTS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2008;5(2 (19)):67-72. Available from: https://sid.ir/paper/78542/en

IEEE: Copy

M.H. MOGHADASI, SH. SAMIEI, S. AMINI KAFIABAD, ZAHRA ATAEI, M. KAVARI, and MARYAM SOBHANI, “THE PREVALENCE OF G20210A GENE MUTATIONAS IN THROMBOTIC PATIENTS,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 5, no. 2 (19), pp. 67–72, 2008, [Online]. Available: https://sid.ir/paper/78542/en

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