Evaluation of the Efficacy of Lentiviral Vectors in Gene Therapy of Beta-thalassemia Patients: A Systematic Review

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Dorgaleleh Saeed; Barahouie Ahmad; Dastaviz Farzad; Ghodsalavi Zahrasadat; OLADNABI MORTEZA

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Journal Paper

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Journal: Journal of Pediatric Perspectives Year:2020 | Volume:8 | Issue:5 (77) Page(s): 11243-11250

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Title

Evaluation of the Efficacy of Lentiviral Vectors in Gene Therapy of Beta-thalassemia Patients: A Systematic Review

Author(s)

Keywords

Beta-thalassemia

Lentiviral

Gene therapy

Vectors

Abstract

Background: Beta thalassemia is a genetic blood abnormality identified through mutations, which reduce the synthesis of the ß-globin chain. Gene therapy through Lentiviral Vectors have cured many of genetic disorders. The purpose of this study was to investigate the efficacy of Lentiviral Vectors in treatment of ß-thalassemia as a novel approach for sustained treatment and prevention of recurrent blood transfusion that has many adverse effects on the patients. Materials and Methods: In this systematic review, a systematic search of online databases (Web of Science, Scopus, and Medline) with no language restriction between 2012 and 2020 using the combination related keywords of Mesh included (Thalassemia OR Beta thalassemia OR β _thalassemia OR BTM) AND (Lentivirus) AND (Genetic therapy OR Gene therapy). All valuable data was allocated, and two independent researchers considered all articles. Results: Finally, 20 articles that met the criteria were selected. Articles were quantitative (n=16), and qualitative (n=4), their year of publication varied from 2012 to 2020. Results showed that the main outcome of the desired survey was therapeutic treatments for thalassemia worldwide. While highly compatible donors for allogeneic bone marrow transplantation are accessible to less than 30% of all patients, Gene therapy has emerged as a holistic and practical approach for the remaining 70%. Conclusion: Nowadays, with the development of Gene therapy, there is hope for a cure for genetic diseases. The successes of Gene therapy techniques can bring laboratory methods of Gene therapy a step closer to clinical and general use as a common treatment for genetic defects.

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APA: Copy

Dorgaleleh, Saeed, Barahouie, Ahmad, Dastaviz, Farzad, Ghodsalavi, Zahrasadat, & OLADNABI, MORTEZA. (2020). Evaluation of the Efficacy of Lentiviral Vectors in Gene Therapy of Beta-thalassemia Patients: A Systematic Review. INTERNATIONAL JOURNAL OF PEDIATRICS, 8(5 (77)), 11243-11250. SID. https://sid.ir/paper/785105/en

Vancouver: Copy

Dorgaleleh Saeed, Barahouie Ahmad, Dastaviz Farzad, Ghodsalavi Zahrasadat, OLADNABI MORTEZA. Evaluation of the Efficacy of Lentiviral Vectors in Gene Therapy of Beta-thalassemia Patients: A Systematic Review. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2020;8(5 (77)):11243-11250. Available from: https://sid.ir/paper/785105/en

IEEE: Copy

Saeed Dorgaleleh, Ahmad Barahouie, Farzad Dastaviz, Zahrasadat Ghodsalavi, and MORTEZA OLADNABI, “Evaluation of the Efficacy of Lentiviral Vectors in Gene Therapy of Beta-thalassemia Patients: A Systematic Review,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 8, no. 5 (77), pp. 11243–11250, 2020, [Online]. Available: https://sid.ir/paper/785105/en

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