INCREASE IN NATURAL AUTO ANTIBODIES AGAINST RBCS IN HEMATOLOGIC DISORDERS

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MOSAED M.; POURFATHOLLAH A.A.; MOGHADAM M.; GUDARZI S.

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Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2017 | Volume:14 | Issue:1 Page(s): 1-7

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Title

INCREASE IN NATURAL AUTO ANTIBODIES AGAINST RBCS IN HEMATOLOGIC DISORDERS

Author(s)

MOSAED M. | POURFATHOLLAH A.A. | MOGHADAM M. | GUDARZI S. | Issue Writer Certificate

Keywords

HEMATOLOGIC DISEASESQ2

ANTIBODIESQ1

RED BLOOD CELLSQ2

Abstract

Background and Objectives In recent years, Natural auto Abs (NAAbs) are considered as key factors in maintaining the immune homeostasis; NAAbs are also known as biomarkers in various diseases. This research, for the first time, was performed to identify NAAbs that are produced against RBCs following some physiologic changes in patients in comparison to healthy blood donors.Materials and Methods In this fundamental-applied research, two groups of samples including 600 healthy blood donors and 324 patients who have shown pathologic disorders participated. All samples were screened for NAAbs but the identification panel was performed only in the case of positive reaction. Results were analyzed through binominal test and by SPSS 16.Results NAAbs were detected in 8.6% of healthy population and 17.9% of the patient population, all determined as positive reactions. Only two cases (1 anti-A1 and1 anti-P1) out of 30 were identifiable among the healthy group with auto antibody; however, in the patient group with auto antibody, 19 anti-IH cases, 1 anti-H cases, 2 anti-I cases, 2 anti-P1 cases, and 6 inconclusive cases were identified.Conclusions A significant difference between the frequency of NAAbs reactions against RBCs in the two groups was observed (p=0.03). Furthermore, anti-IH increases in HEMATOLOGIC DISEASES.

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References

AN ANTIBODY WORTH MENTION

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APA: Copy

MOSAED, M., POURFATHOLLAH, A.A., MOGHADAM, M., & GUDARZI, S.. (2017). INCREASE IN NATURAL AUTO ANTIBODIES AGAINST RBCS IN HEMATOLOGIC DISORDERS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 14(1), 1-7. SID. https://sid.ir/paper/78517/en

Vancouver: Copy

MOSAED M., POURFATHOLLAH A.A., MOGHADAM M., GUDARZI S.. INCREASE IN NATURAL AUTO ANTIBODIES AGAINST RBCS IN HEMATOLOGIC DISORDERS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2017;14(1):1-7. Available from: https://sid.ir/paper/78517/en

IEEE: Copy

M. MOSAED, A.A. POURFATHOLLAH, M. MOGHADAM, and S. GUDARZI, “INCREASE IN NATURAL AUTO ANTIBODIES AGAINST RBCS IN HEMATOLOGIC DISORDERS,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 14, no. 1, pp. 1–7, 2017, [Online]. Available: https://sid.ir/paper/78517/en

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