Protective Effect of Grape Seed Extract on Dexamethasone-Induced Testicular Toxicity in Mice

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHAMADPOUR MASOOMEH; Mollajani Raheleh; SARABANDI FARHAD; HOSSEINI FATEMEH; Mohsenkia Maryam; Erfanizadeh Mahboobeh; SOLEIMANI ALI; Kargar Elias; Mosallaei Halle; Yavarahmadi Mohammadhosein

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Crescent Journal of Medical and Biological Sciences Year:2020 | Volume:7 | Issue:1 Page(s): 59-65

Download Full-Text

View:

211

Download:

107

Cites:

Information Journal Paper

Title

Protective Effect of Grape Seed Extract on Dexamethasone-Induced Testicular Toxicity in Mice

Author(s)

Keywords

Testosterone

Follicle-stimulating hormone

Luteinizing hormone

Dexamethasone

Grape seed extract

Abstract

Objectives: Protracted and repeated exposure to glucocorticoids such as Dexamethasone (Dex) may lead to reproductive dysfunction. In addition, it is a critical cause of male infertility. Grape seed extract (GSE) is an active fraction of a rich source of flavonoids and phenolic procyanidins that is used in traditional Chinese medicine. The purpose of this research was to determine the effect of GSE on testis and Testosterone, Follicle-stimulating hormone (FSH), and Luteinizing hormone (LH) in mice with establishing Dexamethasone. Materials and Methods: To this end, 21 adult male Balb/c mice were divided into control, Dex (7 mg/kg/day i. p), and Dex+GSE (100 mg/kg/d dissolved in 0. 5 mL of olive oil) groups. All the animals in the above-mentioned groups were sacrificed after 35 days, followed by evaluating Testosterone, FSH, and LH levels, spontaneous acrosomal reaction, and testis stereological structure. Results: Significant changes were observed in the normal range of Testosterone, FSH, LH serum levels, spontaneous acrosomal reaction, as well as the number of Sertoli and Leydig cells, spermatogonia, spermatocytes, and spermatids in Dex group compared to the control rats. These parameters changed to a less extent in Dex+GSE animals compared to Dex rats as well. Conclusions: Our findings propose that GSE might have a curative potential on the reproductive system function and its impairment. It is regulated by Dex and reproductive-related hormones.

Cites

Evaluation of Testosterone, Blood Antioxidants, and Histopathological Changes Following Chemical Castration With Calcium Chloride in Rats

References

No record.

Cite

APA: Copy

MOHAMADPOUR, MASOOMEH, Mollajani, Raheleh, SARABANDI, FARHAD, HOSSEINI, FATEMEH, Mohsenkia, Maryam, Erfanizadeh, Mahboobeh, SOLEIMANI, ALI, Kargar, Elias, Mosallaei, Halle, & Yavarahmadi, Mohammadhosein. (2020). Protective Effect of Grape Seed Extract on Dexamethasone-Induced Testicular Toxicity in Mice. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, 7(1), 59-65. SID. https://sid.ir/paper/785188/en

Vancouver: Copy

MOHAMADPOUR MASOOMEH, Mollajani Raheleh, SARABANDI FARHAD, HOSSEINI FATEMEH, Mohsenkia Maryam, Erfanizadeh Mahboobeh, SOLEIMANI ALI, Kargar Elias, Mosallaei Halle, Yavarahmadi Mohammadhosein. Protective Effect of Grape Seed Extract on Dexamethasone-Induced Testicular Toxicity in Mice. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES[Internet]. 2020;7(1):59-65. Available from: https://sid.ir/paper/785188/en

IEEE: Copy

MASOOMEH MOHAMADPOUR, Raheleh Mollajani, FARHAD SARABANDI, FATEMEH HOSSEINI, Maryam Mohsenkia, Mahboobeh Erfanizadeh, ALI SOLEIMANI, Elias Kargar, Halle Mosallaei, and Mohammadhosein Yavarahmadi, “Protective Effect of Grape Seed Extract on Dexamethasone-Induced Testicular Toxicity in Mice,” CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, vol. 7, no. 1, pp. 59–65, 2020, [Online]. Available: https://sid.ir/paper/785188/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops