The Effect of Oral Ibuprofen on Closure of Patent Ductus Arteriosus in Term Neonates: A Clinical Trial Study

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Asadpour Nabiollah; MALEK AHMADI MOHAMMAD REZA; MALEKPOUR AFSANEH; Bagheri Kakolaki Najmeh

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Journal Paper

Paper Information

Journal: Journal of Pediatric Perspectives Year:2020 | Volume:8 | Issue:9 (81) Page(s): 11901-11909

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Title

The Effect of Oral Ibuprofen on Closure of Patent Ductus Arteriosus in Term Neonates: A Clinical Trial Study

Author(s)

Asadpour Nabiollah | MALEK AHMADI MOHAMMAD REZA | MALEKPOUR AFSANEH | Bagheri Kakolaki Najmeh | Issue Writer Certificate

Keywords

Ibuprofen

Patent ductus arteriosus

Term neonate

Abstract

Background: The function of ductus arteriosus closes within a few minutes to a few days after birth in Term neonates. In some cases, the duct remains open after birth, a condition which is called Patent ductus arteriosus (PDA). PDA is associated with high rates of neonatal mortality and morbidity. The present study aims to evaluate the effect of oral Ibuprofen on closure of PDA in Term neonates. Materials and Methods: In this clinical trial, 40 neonates (at the gestational age of 37 weeks and more) aged 5 to 30 days, with confirmed PDA through echocardiography, were randomly divided into two groups (n= 20). One group received Ibuprofen syrup (10 mg/kg body weight) in the first 24 hours, followed by 5 mg/kg body weight for the next four days. The other group received placebo in the same manner. On the seventh day after the beginning of intervention, neonates underwent echocardiography for examination of PDA closure. Side effects of Ibuprofen were evaluated. Symptoms of kidney failure, such as oliguria, edema, and proteinuria and increased creatinine, as well as gastrointestinal side effects such as gastrointestinal bleeding and recurrent vomiting, were assessed for one month. Results: According to the results, PDA diameter was not significantly different in Ibuprofen compared to the placebo groups before (p>0. 05) and after (p>0. 05) intervention. Frequency of PDA closure was 13 (65%) in the Ibuprofen group and 10 (50%) in the placebo group with no significant difference (p>0. 05). There was no significant difference in the mean systolic and diastolic pressure gradient after intervention and in mean changes in pulmonary arterial hypertension between the two groups (p>0. 05). No side effects were observed in any of the groups. Conclusion: Based on the results, oral Ibuprofen did not significantly affect PDA closure in Term neonates.

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References

Oral ibuprofen in full-term neonate's patent ductus arteriosus closure: Discerning the role of prostaglandin, vascular endothelial growth factor, and immature platelet fraction

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APA: Copy

Asadpour, Nabiollah, MALEK AHMADI, MOHAMMAD REZA, MALEKPOUR, AFSANEH, & Bagheri Kakolaki, Najmeh. (2020). The Effect of Oral Ibuprofen on Closure of Patent Ductus Arteriosus in Term Neonates: A Clinical Trial Study. INTERNATIONAL JOURNAL OF PEDIATRICS, 8(9 (81)), 11901-11909. SID. https://sid.ir/paper/785210/en

Vancouver: Copy

Asadpour Nabiollah, MALEK AHMADI MOHAMMAD REZA, MALEKPOUR AFSANEH, Bagheri Kakolaki Najmeh. The Effect of Oral Ibuprofen on Closure of Patent Ductus Arteriosus in Term Neonates: A Clinical Trial Study. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2020;8(9 (81)):11901-11909. Available from: https://sid.ir/paper/785210/en

IEEE: Copy

Nabiollah Asadpour, MOHAMMAD REZA MALEK AHMADI, AFSANEH MALEKPOUR, and Najmeh Bagheri Kakolaki, “The Effect of Oral Ibuprofen on Closure of Patent Ductus Arteriosus in Term Neonates: A Clinical Trial Study,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 8, no. 9 (81), pp. 11901–11909, 2020, [Online]. Available: https://sid.ir/paper/785210/en

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