EVALUATION OF THE ASSOCIATION BETWEEN FGBRS1800790 AND PLASMA FIBRINOGEN LEVELS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MASHAYEKHI A.; SHAHBAZI SH.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2014 | Volume:11 | Issue:1 (43) Page(s): 48-55

Download Full-Text

Persian Verion

View:

786

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF THE ASSOCIATION BETWEEN FGBRS1800790 AND PLASMA FIBRINOGEN LEVELS

Author(s)

MASHAYEKHI A. | SHAHBAZI SH. | Issue Writer Certificate

Keywords

FIBRINOGENQ2

GENETIC POLYMORPHISMQ3

RFLPQ3

Abstract

Background and Objectives FIBRINOGEN, coagulation factor 1, is a soluble plasma glycoprotein which converts thrombin to fibrin fibers in the coagulation cascade. Various polymorphisms located on beta chain gene, FGB, have been studied. The promoter – G455A (rs1800790) polymorphism had been shown to be significantly associated with FIBRINOGEN plasma levels. In this study, the frequency of rs1800790 polymorphism has been assessed and the correlation was evaluated between this variant and FIBRINOGEN plasma levels.Materials and Methods Whole blood samples were collected for DNA isolation. To perform rs1800790 genotyping, the region encompassing the HaeIII restriction site was amplified using specific primers. The plasma levels of FIBRINOGEN were measured and the obtained data were analyzed by SPSS software.Results The levels of plasma FIBRINOGEN has shown a significant correlation with FGBrs1800790 genotype (p-value=0.021; CI=0.347- 3.253). Minor allele frequency was estimated to be 0.28 which was consistent with the predicted value.Conclusions The significant correlation between FIBRINOGEN and FGBrs1800790 genotype emphasizes the importance of this variant in the modulation of FIBRINOGEN plasma concentrations. Since FGBrs1800790 contributes to the gene expression and environmental risk factors, it is important to be noticed in the cardiovascular disease.

Cites

No record.

References

Cite

APA: Copy

MASHAYEKHI, A., & SHAHBAZI, SH.. (2014). EVALUATION OF THE ASSOCIATION BETWEEN FGBRS1800790 AND PLASMA FIBRINOGEN LEVELS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 11(1 (43)), 48-55. SID. https://sid.ir/paper/78548/en

Vancouver: Copy

MASHAYEKHI A., SHAHBAZI SH.. EVALUATION OF THE ASSOCIATION BETWEEN FGBRS1800790 AND PLASMA FIBRINOGEN LEVELS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2014;11(1 (43)):48-55. Available from: https://sid.ir/paper/78548/en

IEEE: Copy

A. MASHAYEKHI, and SH. SHAHBAZI, “EVALUATION OF THE ASSOCIATION BETWEEN FGBRS1800790 AND PLASMA FIBRINOGEN LEVELS,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 11, no. 1 (43), pp. 48–55, 2014, [Online]. Available: https://sid.ir/paper/78548/en

Related Journal Papers