STUDY OF BETA-FIBRINOGEN-455 G/A POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION

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KAHRIZI KIMIA; OBERKANINS CHRISTIAN; HADAVI VALEH; BOZORGMEHR BITA; NAJMABADI HOSSEIN

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Journal: GENETICS IN THE 3RD MILLENNIUM Year:2010 | Volume:8 | Issue:1 Page(s): 1957-1961

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Title

STUDY OF BETA-FIBRINOGEN-455 G/A POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION

Author(s)

Keywords

VENOUS THROMBOEMBOLISMQ3

POLYMORPHISMQ3

GENETICQ3

FIBRINOGENQ3

GENE FREQUENCYQ2

IRANQ2

Abstract

Two hundred and eight asymptomatic individuals from different origins of IRAN were included in this study in order to assess the distribution of the b-Fibrinogen -455 G/A POLYMORPHISM responding for cardiovascular disease (CVD) in the general IRANian population using a novel technique reverse hybridization StripAssay for the rapid and simultaneous detection. The test is based on multiplex PCR and hybridization to a teststrip presenting a parallel array of allele-specific oligonucleotide probes. The allele frequency of mutant FGB -455 G/A (0.22) is comparable to that of Europeans, but exceeded the much lower frequencies known from the most of Asia. Here we describe the distribution of mutant allele FGB -455 G/A in different ethnicities of IRANian population. Our data represent the only comprehensive study to date with respect to thrombophilic gene POLYMORPHISM in IRAN.

Cites

EVALUATION OF THE ASSOCIATION BETWEEN FGBRS1800790 AND PLASMA FIBRINOGEN LEVELS

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APA: Copy

KAHRIZI, KIMIA, OBERKANINS, CHRISTIAN, HADAVI, VALEH, BOZORGMEHR, BITA, & NAJMABADI, HOSSEIN. (2010). STUDY OF BETA-FIBRINOGEN-455 G/A POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION. GENETICS IN THE 3RD MILLENNIUM, 8(1), 1957-1961. SID. https://sid.ir/paper/117218/en

Vancouver: Copy

KAHRIZI KIMIA, OBERKANINS CHRISTIAN, HADAVI VALEH, BOZORGMEHR BITA, NAJMABADI HOSSEIN. STUDY OF BETA-FIBRINOGEN-455 G/A POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION. GENETICS IN THE 3RD MILLENNIUM[Internet]. 2010;8(1):1957-1961. Available from: https://sid.ir/paper/117218/en

IEEE: Copy

KIMIA KAHRIZI, CHRISTIAN OBERKANINS, VALEH HADAVI, BITA BOZORGMEHR, and HOSSEIN NAJMABADI, “STUDY OF BETA-FIBRINOGEN-455 G/A POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION,” GENETICS IN THE 3RD MILLENNIUM, vol. 8, no. 1, pp. 1957–1961, 2010, [Online]. Available: https://sid.ir/paper/117218/en

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