SIMVASTATIN SYNERGISTICALLY POTENTIATING THE ANTI-TUMOREFFECTS OF ARSENIC TRIOXIDE ON HUMAN PROMYELOCYTIC LEUKEMIA (NB-4) CELLS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHANIZADEH VESALI S.; SHIRALI S.; ZAKER F.; MOHAMMADI S.; ARYANPOUR J.; YAZDANPARAST S.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2014 | Volume:11 | Issue:2 Page(s): 116-125

Download Full-Text

Persian Verion

View:

997

Download:

Cites:

Information Journal Paper

Title

SIMVASTATIN SYNERGISTICALLY POTENTIATING THE ANTI-TUMOREFFECTS OF ARSENIC TRIOXIDE ON HUMAN PROMYELOCYTIC LEUKEMIA (NB-4) CELLS

Author(s)

Keywords

ACUTE PROMYELOCYTIC LEUKEMIAQ2

ARSENIC TRIOXIDEQ3

SIMVASTATINQ2

APOPTOSISQ2

Abstract

Background and Objectives: The efficacy of ARSENIC TRIOXIDE (ATO), as a poisonous drug, in the treatment of ACUTE PROMYELOCYTIC LEUKEMIA (APL) is widely accepted. Due to adverse effects associated with high-dose ATO, the combination therapy is a rational therapeutic strategy to enhance the effectiveness of ATO. In this regard, we used SIMVASTATIN (SV), a cholesterol lowering medication, and hypothesized that SV plus ATO would potentiate the efficacy of ATO at lower doses.Materials and Methods: To evaluate the effects of SV and ATO treatment (in isolation or in combination) on transcriptional levels of Bax and Bcl-2, APOPTOSIS, growth kinetic, and metabolic activity of NB-4 cells, we employed RQ-PCR, flowcytometry, trypan blue dye exclusion, and MTT assays, respectively. The data were analyzed using SPSS 21, student’s t-test and one-way ANOVA tests.Results: Both SV and ATO considerably hindered the metabolic activity of NB-4 cells in a concentration-dependent manner. In addition, the co-treatment with them exerted an indicative decline in viability, and a significant augmentation in apoptotic population and in the ratio of Bax to Bcl-2 mRNA level.Conclusions: Our results have demonstrated that ATO and SV cooperate synergistically to induce cell death and to inhibit the proliferation rate of NB-4 cells. Furthermore, our results suggest that the combination treatment increased the programmed cell death rate probably through enhancing the intrinsic mitochondrial apoptotic pathway. On aggregate and in view of these data, SV showed the potency for attenuating the effective dose of ATO.

Cites

No record.

References

Cite

APA: Copy

GHANIZADEH VESALI, S., SHIRALI, S., ZAKER, F., MOHAMMADI, S., ARYANPOUR, J., & YAZDANPARAST, S.A.. (2014). SIMVASTATIN SYNERGISTICALLY POTENTIATING THE ANTI-TUMOREFFECTS OF ARSENIC TRIOXIDE ON HUMAN PROMYELOCYTIC LEUKEMIA (NB-4) CELLS . THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 11(2), 116-125. SID. https://sid.ir/paper/78607/en

Vancouver: Copy

GHANIZADEH VESALI S., SHIRALI S., ZAKER F., MOHAMMADI S., ARYANPOUR J., YAZDANPARAST S.A.. SIMVASTATIN SYNERGISTICALLY POTENTIATING THE ANTI-TUMOREFFECTS OF ARSENIC TRIOXIDE ON HUMAN PROMYELOCYTIC LEUKEMIA (NB-4) CELLS . THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2014;11(2):116-125. Available from: https://sid.ir/paper/78607/en

IEEE: Copy

S. GHANIZADEH VESALI, S. SHIRALI, F. ZAKER, S. MOHAMMADI, J. ARYANPOUR, and S.A. YAZDANPARAST, “SIMVASTATIN SYNERGISTICALLY POTENTIATING THE ANTI-TUMOREFFECTS OF ARSENIC TRIOXIDE ON HUMAN PROMYELOCYTIC LEUKEMIA (NB-4) CELLS ,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 11, no. 2, pp. 116–125, 2014, [Online]. Available: https://sid.ir/paper/78607/en

Related Journal Papers