RELATIONSHIP BETWEEN GPIA(807C/T) AND GPIIIA (PLA1/PLA2) GENE PLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION IN WOMEN IN TEHRAN PROVINCE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MAZIRI P.; ASAADI TEHRANI G.; MIRZAAHMADI S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2016 | Volume:13 | Issue:2 Page(s): 138-145

Download Full-Text

Persian Verion

View:

758

Download:

Cites:

Information Journal Paper

Title

RELATIONSHIP BETWEEN GPIA(807C/T) AND GPIIIA (PLA1/PLA2) GENE PLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION IN WOMEN IN TEHRAN PROVINCE

Author(s)

MAZIRI P. | ASAADI TEHRANI G. | MIRZAAHMADI S. | Issue Writer Certificate

Keywords

SPONTANEOUS ABORTIONQ2

GPIAQ2

GPIIIAQ2

Abstract

Background and Objectives: Recurrent SPONTANEOUS ABORTION is defined as pregnancy loss before the 20th week of gestation. In some women with history of consecutive miscarriage, thrombophilic gene mutations lead to blood clots in vessels in placenta, decrease oxygen delivery, and end to fetal loss. This study aimed to determine the association of 807C/T (GPIa gene) and PLA1/PLA2 (GPIIIa gene) polymorphisms in RSA.Materials and Methods: In this case-control study, 50 women with the background of two or more consecutive unexplained abortions and 50 women with at least two live births without a miscarriage were selected in Tehran province and they were examined in Biology Research Center of Islamic Azad University Zanjan (Iran) in 2014. The 807C/T and PLA1/PLA2 polymorphisms were analyzed by Tetra-Primer ARMS-PCR and PCR-RFLP methods, respectively. The results achieved from estimating the genotype of these polymorphisms were analyzed by the SPSS16 and Chi Square.Results: Compared to the control population, there was an increase in the prevalence of the homozygous 807TT genotype in the case group (p=0.045), but the prevalence of homozygous PLA2/PLA2 genotype decreased in two groups (p=0.467). We reported the prevalence of 807T/T and PLA2/PLA2 genotypes as (0.34, 0.16) and (0.06, 0.02) for patients and controls, respectively.Conclusions: The results of the present study showed that 807C/T polymorphism has a correlation with RPA but there is no significant difference between patient and normal groups in PLA1/PLA2.

Cites

No record.

References

Cite

APA: Copy

MAZIRI, P., ASAADI TEHRANI, G., & MIRZAAHMADI, S.. (2016). RELATIONSHIP BETWEEN GPIA(807C/T) AND GPIIIA (PLA₁/PLA₂) GENE PLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION IN WOMEN IN TEHRAN PROVINCE. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 13(2), 138-145. SID. https://sid.ir/paper/78684/en

Vancouver: Copy

MAZIRI P., ASAADI TEHRANI G., MIRZAAHMADI S.. RELATIONSHIP BETWEEN GPIA(807C/T) AND GPIIIA (PLA₁/PLA₂) GENE PLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION IN WOMEN IN TEHRAN PROVINCE. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2016;13(2):138-145. Available from: https://sid.ir/paper/78684/en

IEEE: Copy

P. MAZIRI, G. ASAADI TEHRANI, and S. MIRZAAHMADI, “RELATIONSHIP BETWEEN GPIA(807C/T) AND GPIIIA (PLA₁/PLA₂) GENE PLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION IN WOMEN IN TEHRAN PROVINCE,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 13, no. 2, pp. 138–145, 2016, [Online]. Available: https://sid.ir/paper/78684/en

Related Journal Papers