EFFECT OF KOMBUCHA TEA ON RAT LIVER HISTOPHATOLOGICAL ALTERATIONS DUE TO THIOACETAMIDE

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KABIRI N.; AHANGAR DARABI M.; MAHZOONI P.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: Journal of Gorgan University of Medical Sciences Year:2014 | Volume:15 | Issue:4 (48) Page(s): 35-41

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Information Journal Paper

Title

EFFECT OF KOMBUCHA TEA ON RAT LIVER HISTOPHATOLOGICAL ALTERATIONS DUE TO THIOACETAMIDE

Author(s)

KABIRI N. | AHANGAR DARABI M. | MAHZOONI P. | Issue Writer Certificate

Keywords

KOMBUCHA TEAQ2

THIOACETAMIDEQ1

LIVERQ2

ENZYMQ2

RATQ2

Abstract

Background and Objective: Kombucha (fungal) tea is a sugar sweetened black tea obtained through a fermentation process containing symbiotic culture of acetic acid bacteria and yeasts. This study was done to determine the effect of KOMBUCHA TEA on RAT LIVER histophatological alterations due to THIOACETAMIDE (TAA).Materials and Methods: In this experimental study, 20 adult male Wistar RATs randomly allocated into four groups as follow: 1) control, 2) TAA group, treated with (TAA), (400 mg/kg/bw) for two weeks, 3) treated with (TAA), (400 mg/kg/bw) and then with KOMBUCHA TEA (50 mg/kg) and finally 4) preventive, treated with KOMBUCHA TEA, (50 mg/kg) and then (TAA), (400 mg/kg) for three weeks. The serum level of aminotransferase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and total bilirubin were meseared and LIVER tissue samples were stained by hematoxilin and eosin.Results: Serum level of AST, ALT, ALP, LDH and total bilirubin significantly increased in TAA group compare to control group (P<0.05). Serum level of AST, ALT, ALP, LDH and total bilirubin significantly reduced in treated and protective groups in comparision with TAA group (P<0.05). Mitosis and apptosis increased in TAA group. These LIVER histopathological alterations reduced in terated and protective groups.Conclusion: KOMBUCHA TEA contains theraputic and protective effects on ENZYMs and LIVER histophatological damage due to THIOACETAMIDE in RAT.

Cites

Evaluating the effect of curcumin on Thioacetamide-induced liver in maturemale rats

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APA: Copy

KABIRI, N., AHANGAR DARABI, M., & MAHZOONI, P.. (2014). EFFECT OF KOMBUCHA TEA ON RAT LIVER HISTOPHATOLOGICAL ALTERATIONS DUE TO THIOACETAMIDE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 15(4 (48)), 35-41. SID. https://sid.ir/paper/78870/en

Vancouver: Copy

KABIRI N., AHANGAR DARABI M., MAHZOONI P.. EFFECT OF KOMBUCHA TEA ON RAT LIVER HISTOPHATOLOGICAL ALTERATIONS DUE TO THIOACETAMIDE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;15(4 (48)):35-41. Available from: https://sid.ir/paper/78870/en

IEEE: Copy

N. KABIRI, M. AHANGAR DARABI, and P. MAHZOONI, “EFFECT OF KOMBUCHA TEA ON RAT LIVER HISTOPHATOLOGICAL ALTERATIONS DUE TO THIOACETAMIDE,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 4 (48), pp. 35–41, 2014, [Online]. Available: https://sid.ir/paper/78870/en

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