INCIDENCE OF GROSS CONGENITAL MALFORMATIONS AFTER SHORT-TERM EXPOSURE TO ALUMINIUM CHLORIDE IN MICE

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TORABI ZADEH G.; KARIMPOUR A.; SADUGHI M.; DARABI SS.

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Journal: Journal of Gorgan University of Medical Sciences Year:2005 | Volume:6 | Issue:14 Page(s): 10-14

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Title

INCIDENCE OF GROSS CONGENITAL MALFORMATIONS AFTER SHORT-TERM EXPOSURE TO ALUMINIUM CHLORIDE IN MICE

Author(s)

TORABI ZADEH G. | KARIMPOUR A. | SADUGHI M. | DARABI SS. | Issue Writer Certificate

Keywords

ALUMINIUM CHLORIDEQ4

TERATOGENQ3

BIRTH DEFECTQ3

MOUSE EMBRYOQ4

Abstract

Background&Objective: Aluminium (Al), the third common element in the earth’s crust has a significant toxin potential for humans. Although the knowledge of AL toxicity has markedly improved in recent years, there is relatively little information regarding the embryotoxic and teratogenic potential of AL. The purpose of this study was to assess the effect of a short-term exposure of pregnant mice to ALUMINIUM CHLORIDE on the external organ formation of their fetuses. Materials&Methods: Mature NMRI mice (24-33g) were used in this study. Day 0 of pregnancy defined as the day in which the vaginal plug was found. Plug-positive mice were randomly divided into size groups. The first, secound and third groups of animals were given IP injection of single dose of Alcl3 at 150 mg/kg/day on days 10, 11 and 12 of gestation respectively. Mice in the 3 other groups (controls) received single injection of 0.3ml saline on days 10,11 and 12 respectively. Mice were killed on day 15 of gestation. Live fetuses were weighed and examined for external abnormalities. Results: The fetal body weight was significantly reduced in all Al-treated groups (P<0.05). The proportions of external malformations in 10th, 11th and 12th days treated were 47.0%, 37.0% and 33.1% groups respectively with significantly increase comparing to controls (P<0.05). Conclusion: It is concluded that a single dose of the AL administered to pregnant mice can cause external malformations in their fetuses.

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APA: Copy

TORABI ZADEH, G., KARIMPOUR, A., SADUGHI, M., & DARABI, SS.. (2005). INCIDENCE OF GROSS CONGENITAL MALFORMATIONS AFTER SHORT-TERM EXPOSURE TO ALUMINIUM CHLORIDE IN MICE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 6(14), 10-14. SID. https://sid.ir/paper/79060/en

Vancouver: Copy

TORABI ZADEH G., KARIMPOUR A., SADUGHI M., DARABI SS.. INCIDENCE OF GROSS CONGENITAL MALFORMATIONS AFTER SHORT-TERM EXPOSURE TO ALUMINIUM CHLORIDE IN MICE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2005;6(14):10-14. Available from: https://sid.ir/paper/79060/en

IEEE: Copy

G. TORABI ZADEH, A. KARIMPOUR, M. SADUGHI, and SS. DARABI, “INCIDENCE OF GROSS CONGENITAL MALFORMATIONS AFTER SHORT-TERM EXPOSURE TO ALUMINIUM CHLORIDE IN MICE,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 6, no. 14, pp. 10–14, 2005, [Online]. Available: https://sid.ir/paper/79060/en

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