EFFECT OF GRAPE SEED OIL (VITIS VINIFERA) ON SERUM GONADOTROPINS AND TESTOSTERONE LEVELS IN ADULT RATS EXPOSED TO LEAD ACETATE

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MOKHTARI M.; JELVEH S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Gorgan University of Medical Sciences Year:2015 | Volume:17 | Issue:1 (53) Page(s): 36-41

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Title

EFFECT OF GRAPE SEED OIL (VITIS VINIFERA) ON SERUM GONADOTROPINS AND TESTOSTERONE LEVELS IN ADULT RATS EXPOSED TO LEAD ACETATE

Author(s)

MOKHTARI M. | JELVEH S. | Issue Writer Certificate

Keywords

GRAPE SEEDQ2

LEAD ACETATEQ2

LHQ2

FSHQ2

TESTOSTERONEQ2

RATQ2

Abstract

Background and Objective: Lead exposure induced toxic effects on reproductive system. This study was done to evaluate the effect of GRAPE SEED oil (Vitis vinifera) on serum gonadotropins and TESTOSTERONE level in toxicited adult male RATs by LEAD ACETATE.Methods: In this experimental study, 56 adult male Wistar RATs were randomly allocated equally into 7 groups. Animals in control group did not receive any matter. Animals in the sham, experimental 1 and experimental 2 groups were received orally distilled water, 8ml/kg GRAPE SEED oil (GSO) and 0.1 mmol/lit LEAD ACETATE for 21 days, respectively. Animals in the experimental group 3, 4 and 5 were received 0.1 mmol/lit LEAD ACETATE for 21 days and then 2 ml/kg/bw, 4 ml/kg/bw and 8ml/kg/bw GSO from day 22 up to day 42, recpectively. Blood samples were taken from control, sham and experimental groups 1 and 2 at the end of day 21. At the end of day 42, blood samples were taken from experimental groups 3, 4 and 5. Serum level of LH, FSH and TESTOSTERONE were measured by Radioimmunoassay.Results: Serum level of LH, FSH and TESTOSTERONE were significantly reduced in the experimental group 2 in compared to control group. Serum level of LH, FSH and TESTOSTERONE were significantly increased in experimental group 4 and 5 in comparision with the experimental group 2.Conclusion: GRAPE SEED oil extract at doses of 4 and 8ml/kg/bw increased serum level of LH, FSH and TESTOSTERONE in LEAD ACETATE exposed male RATs.

Cites

PROTECTIVE EFFECTS OF ELETTARIA CARDAMOMUM L. HYDROALCOHOLIC EXTRACT ON SERUM LEVELS OF GONADOTROPINS AND TESTOSTERONE IN ADULT MALE WISTAR RATS INDUCED WITH LEAD ACETATE

References

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APA: Copy

MOKHTARI, M., & JELVEH, S.. (2015). EFFECT OF GRAPE SEED OIL (VITIS VINIFERA) ON SERUM GONADOTROPINS AND TESTOSTERONE LEVELS IN ADULT RATS EXPOSED TO LEAD ACETATE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 17(1 (53)), 36-41. SID. https://sid.ir/paper/79674/en

Vancouver: Copy

MOKHTARI M., JELVEH S.. EFFECT OF GRAPE SEED OIL (VITIS VINIFERA) ON SERUM GONADOTROPINS AND TESTOSTERONE LEVELS IN ADULT RATS EXPOSED TO LEAD ACETATE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;17(1 (53)):36-41. Available from: https://sid.ir/paper/79674/en

IEEE: Copy

M. MOKHTARI, and S. JELVEH, “EFFECT OF GRAPE SEED OIL (VITIS VINIFERA) ON SERUM GONADOTROPINS AND TESTOSTERONE LEVELS IN ADULT RATS EXPOSED TO LEAD ACETATE,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 1 (53), pp. 36–41, 2015, [Online]. Available: https://sid.ir/paper/79674/en

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