THE EFFECTS OF DICLOFENAC AND IBUPROFEN ON HEK CELLS IN CELL CULTURE

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AHMADI R.; SAGHARJOGHI FARAHANI M.; AZADKHAH R.

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Journal: Yafteh Year:2017 | Volume:19 | Issue:4 (73) Page(s): 68-75

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Title

THE EFFECTS OF DICLOFENAC AND IBUPROFEN ON HEK CELLS IN CELL CULTURE

Author(s)

AHMADI R. | SAGHARJOGHI FARAHANI M. | AZADKHAH R. | Issue Writer Certificate

Keywords

DICLOFENACQ2

IBUPROFENQ2

HEKQ1

VIABILITYQ1

Abstract

Background: The studies show that the DICLOFENAC and IBUPROFEN drugs influence cancer cells proliferation. The main aim of this study was to investigate the effects of DICLOFENAC and IBUPROFEN on the VIABILITY of HEK cells in cell culture.Materials and Methods: In this laboratory experimental study, HEK cells were randomly divided into control group and groups exposed doses to 0.001, 0.01, 0.1, 10, 1 mg/ml of IBUPROFEN and DICLOFENAC. The toxic effect of drugs was measured using the MTT assay method. The data were statistically analyzed between groups using ANOVA.Results: The VIABILITY of HEK cells exposed to 0.1, 0.01, 0.001 mg/ml of IBUPROFEN was not significant increase in compared with control group. And the VIABILITY of HEK cells exposed to 1, 10, 0.1, 0.01, 0.001 mg/ml of DICLOFENAC significantly decreased compared to control group.(Classification P<0.01, P<0.01, P<0.01, P<0.05, P<0.01).Conclusion: DICLOFENAC and IBUPROFEN in high doses destroy the HEK cells. Therefore, the use of these drugs in high doses is inappropriate.

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APA: Copy

AHMADI, R., SAGHARJOGHI FARAHANI, M., & AZADKHAH, R.. (2017). THE EFFECTS OF DICLOFENAC AND IBUPROFEN ON HEK CELLS IN CELL CULTURE. YAFTEH, 19(4 (73)), 68-75. SID. https://sid.ir/paper/79901/en

Vancouver: Copy

AHMADI R., SAGHARJOGHI FARAHANI M., AZADKHAH R.. THE EFFECTS OF DICLOFENAC AND IBUPROFEN ON HEK CELLS IN CELL CULTURE. YAFTEH[Internet]. 2017;19(4 (73)):68-75. Available from: https://sid.ir/paper/79901/en

IEEE: Copy

R. AHMADI, M. SAGHARJOGHI FARAHANI, and R. AZADKHAH, “THE EFFECTS OF DICLOFENAC AND IBUPROFEN ON HEK CELLS IN CELL CULTURE,” YAFTEH, vol. 19, no. 4 (73), pp. 68–75, 2017, [Online]. Available: https://sid.ir/paper/79901/en

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