COMPARISON OF THE ANTIFUNGAL EFFECTS OF VARIOUS EXTRACTS OF ONOSMA CHLOROTRICUM ON CANDIDA ALBICANS AND CANDIDA GLABERATA WITH TWO ANTIBIOTICS FLUCONAZOLE AND NYSTATIN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NABIPOUR F.; DOUSTI B.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Yafteh Year:2018 | Volume:20 | Issue:1 (75) Page(s): 12-22

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,364

Download:

Cites:

Information Journal Paper

Title

COMPARISON OF THE ANTIFUNGAL EFFECTS OF VARIOUS EXTRACTS OF ONOSMA CHLOROTRICUM ON CANDIDA ALBICANS AND CANDIDA GLABERATA WITH TWO ANTIBIOTICS FLUCONAZOLE AND NYSTATIN

Author(s)

NABIPOUR F. | DOUSTI B. | Issue Writer Certificate

Keywords

FLUCONAZOLEQ3

NYSTATINQ1

ANTIFUNGALQ1

EXTRACTQ2

ONOSMA CHLOROTRICUMQ1

Abstract

Background: Because of the recurrence of Candida infections, their resistance to ANTIFUNGAL drugs during treatment, the known side effects of chemical drugs, and the existence of some studies that Onosma's genus contains derivatives of alkannin and shikonin that have ANTIFUNGAL properties, for the first time, the ANTIFUNGAL properties of ONOSMA CHLOROTRICUM were compared with antibiotics.Materials and Methods: The plant was collected from Koohdasht in July of 2016, and after detection and drying, N- hexane, methanol, aqueous EXTRACTs of plants were prepared by soaking.The ANTIFUNGAL effects of different concentrations of EXTRACTs were studied by the disc diffusion method and determination of MIC (minimum inhibitory concentration of growth), MFC (minimum fungicidal concentration) was done by microdilution method. Antibiotics FLUCONAZOLE and NYSTATINe were used as a positive control and DMSO was used as a negative control. Data were analyzed by t-test and one-way ANOVA.Results: The mean inhibitory diameter of growth of the hexane EXTRACT in concentration of 10 mg / ml was higher than NYSTATIN antibiotic inhibitory diameter of growth for Candida albicans and Candida glaberata (P˂0.05). The lowest MIC for Candida albicans and Candida glaberata was respectively, 15.62 and 31.25 mg / ml, and the lowest MFC for Candida albicans and Candida glaberata was 31.25 and 62.5. mg / ml.Conclusion: EXTRACTs of this plant showed ANTIFUNGAL effect on Candida albicans and glaberata.The possibility of using this EXTRACT in the treatment of Candida infection requires the completion of supplementary studies.

Cites

Evaluation of the Antifungal effects of various Extracts of the Aerial part and Root of Echium italicum on Candida albicans compared with two common antibiotics

References

Cite

APA: Copy

NABIPOUR, F., & DOUSTI, B.. (2018). COMPARISON OF THE ANTIFUNGAL EFFECTS OF VARIOUS EXTRACTS OF ONOSMA CHLOROTRICUM ON CANDIDA ALBICANS AND CANDIDA GLABERATA WITH TWO ANTIBIOTICS FLUCONAZOLE AND NYSTATIN. YAFTEH, 20(1 (75) ), 12-22. SID. https://sid.ir/paper/80046/en

Vancouver: Copy

NABIPOUR F., DOUSTI B.. COMPARISON OF THE ANTIFUNGAL EFFECTS OF VARIOUS EXTRACTS OF ONOSMA CHLOROTRICUM ON CANDIDA ALBICANS AND CANDIDA GLABERATA WITH TWO ANTIBIOTICS FLUCONAZOLE AND NYSTATIN. YAFTEH[Internet]. 2018;20(1 (75) ):12-22. Available from: https://sid.ir/paper/80046/en

IEEE: Copy

F. NABIPOUR, and B. DOUSTI, “COMPARISON OF THE ANTIFUNGAL EFFECTS OF VARIOUS EXTRACTS OF ONOSMA CHLOROTRICUM ON CANDIDA ALBICANS AND CANDIDA GLABERATA WITH TWO ANTIBIOTICS FLUCONAZOLE AND NYSTATIN,” YAFTEH, vol. 20, no. 1 (75) , pp. 12–22, 2018, [Online]. Available: https://sid.ir/paper/80046/en

Related Journal Papers