SERUM HOMOCYSTEINE, VITAMIN 812 AND FOLATE LEVELS IN PATIENTS WITH ISCHEMIC CEREBROVASCULARE DISEASE

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MONSHI KARIMI A.R.; MOHTADINIA J.; FARHOUDI MAHDI

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Journal: Yafteh Year:2007 | Volume:9 | Issue:3 (33) Page(s): 29-34

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Title

SERUM HOMOCYSTEINE, VITAMIN 812 AND FOLATE LEVELS IN PATIENTS WITH ISCHEMIC CEREBROVASCULARE DISEASE

Author(s)

MONSHI KARIMI A.R. | MOHTADINIA J. | FARHOUDI MAHDI | Issue Writer Certificate

Keywords

CEREBROVASCULAR EVENTSQ3

ISCHEMIAQ2

VITAMIN B12Q3

FOLIC ACIDQ3

HOMOCYSTEINEQ3

Abstract

Background: Ischemic is one of the major causes of death and inabilities in the world. Environmental and nutritional risk Factors such as inadequate intake of VITAMIN B12 and FOLIC ACID followed by high serum total HOMOCYSTEINE concentration. increases the risk of cerebrovascular diseases. The aim of this study was to compare serum level of homocysteine, VITAMIN B12 and FOLIC ACID in Ischemic patients and healthy controls. Materials and methods: In this case-control study, 45 inpatients subjects (30 M,16 F aged 45-75 years)and 45 age sex matched healthy subjects (29 M and 16 F) were selected. 5ml blood was take for each subject and serum level of HOMOCYSTEINE (using ELISA), VITAMIN B12 and folate (using RIA) were measured. Results: There were no significant differences in age and BMI between canes and controls. The Serum HOMOCYSTEINE level in controls war higher than in controls (18.68 mmol/L ±1.53 vs 9.96mmol/L±0.9, P<0.001) while Serum VITAMIN B12 and folate concentrations in patients were lower than in controls 394.28 Pmol/L ±19.39 vs 631.60pmol/L ±33.1vs 1.53ngml ±0.08,P<0.001, respectively). Serum HOMOCYSTEINE was inversely and significantly Correlated with serum folate Changes and VITAMIN B12. 8% and 10% Changes in HOMOCYSTEINE level were explained by Changes in Serum folate and VITAMIN B12. Conclusion: As Low intakes of VITAMIN B12 and FOLIC ACID result in high HOMOCYSTEINE concentration and consequently higher risk for Ischemic cerebrovasular events, proper diet including adequate intake of these vitamins is suggested.

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APA: Copy

MONSHI KARIMI, A.R., MOHTADINIA, J., & FARHOUDI, MAHDI. (2007). SERUM HOMOCYSTEINE, VITAMIN 812 AND FOLATE LEVELS IN PATIENTS WITH ISCHEMIC CEREBROVASCULARE DISEASE. YAFTEH, 9(3 (33)), 29-34. SID. https://sid.ir/paper/80132/en

Vancouver: Copy

MONSHI KARIMI A.R., MOHTADINIA J., FARHOUDI MAHDI. SERUM HOMOCYSTEINE, VITAMIN 812 AND FOLATE LEVELS IN PATIENTS WITH ISCHEMIC CEREBROVASCULARE DISEASE. YAFTEH[Internet]. 2007;9(3 (33)):29-34. Available from: https://sid.ir/paper/80132/en

IEEE: Copy

A.R. MONSHI KARIMI, J. MOHTADINIA, and MAHDI FARHOUDI, “SERUM HOMOCYSTEINE, VITAMIN 812 AND FOLATE LEVELS IN PATIENTS WITH ISCHEMIC CEREBROVASCULARE DISEASE,” YAFTEH, vol. 9, no. 3 (33), pp. 29–34, 2007, [Online]. Available: https://sid.ir/paper/80132/en

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