EVALUATION OF THE SERUM CONCENTRATIONS OF ALBUMIN AND URIC ACID AS ABIOMARKER IN PATIENTS WITH PARKINSON'S DISEASE

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HEMMATI DINARVAND M.; SAEDI S.; KALANTARY CHARVADEH A.; BAGHERI SH.; MOTA A.; VALILOO M.

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Journal: Yafteh Year:2018 | Volume:20 | Issue:3 (77) Page(s): 39-47

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Title

EVALUATION OF THE SERUM CONCENTRATIONS OF ALBUMIN AND URIC ACID AS ABIOMARKER IN PATIENTS WITH PARKINSON'S DISEASE

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Keywords

ALBUMINQ2

URIC ACIDQ2

BIOMARKERQ1

PARKINSON'S DISEASEQ2

Abstract

Background: PARKINSON'S DISEASE (PD) is a neurological disorder in which dopamine-producingneurons are destroyed. This disease is associated with aging. Our aim in this study was to measurethe serum concentrations of ALBUMIN and URIC ACID (UA) as a BIOMARKER for PD detection. Materials and Methods: In this case-control study, we recruited 40 Parkinson patients and 40healthy individuals. Blood samples (5 ml) were collected from both groups and the serum wasisolated. Serum ALBUMIN and UA levels were measured, and the data was analyzed by SPSSsoftware, and graphs were prepared using Graphpad Prism. Results: Our results showed that the serum levels of ALBUMIN were significantly higher in thecontrol group (5. 69 ± 2. 51 g/dl) compared to the patient group (4. 12 ± 1. 60 g/dl) (p˂ 0. 001). On theother hand, the serum concentrations of UA in the control group (5. 18 ± 1. 28 mg/dl) were notstatistically significantly different in comparison with the patient group (5. 01 ± 1. 34 mg/dl) (p=0. 56). The ROC analysis used to evaluate the diagnostic value of BIOMARKERs for PD. ALBUMIN wasshown to have a high capability for separating patients from healthy subjects, with an area under theROC curve 0. 85, sensitivity 60% and specificity 97%. Conclusion: The findings of this study indicate that serum ALBUMIN levels in patients with PD arelower than healthy subject, and maybe in the future this can be used as diagnostic criteria.

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APA: Copy

HEMMATI DINARVAND, M., SAEDI, S., KALANTARY CHARVADEH, A., BAGHERI, SH., MOTA, A., & VALILOO, M.. (2018). EVALUATION OF THE SERUM CONCENTRATIONS OF ALBUMIN AND URIC ACID AS ABIOMARKER IN PATIENTS WITH PARKINSON'S DISEASE. YAFTEH, 20(3 (77) ), 39-47. SID. https://sid.ir/paper/80152/en

Vancouver: Copy

HEMMATI DINARVAND M., SAEDI S., KALANTARY CHARVADEH A., BAGHERI SH., MOTA A., VALILOO M.. EVALUATION OF THE SERUM CONCENTRATIONS OF ALBUMIN AND URIC ACID AS ABIOMARKER IN PATIENTS WITH PARKINSON'S DISEASE. YAFTEH[Internet]. 2018;20(3 (77) ):39-47. Available from: https://sid.ir/paper/80152/en

IEEE: Copy

M. HEMMATI DINARVAND, S. SAEDI, A. KALANTARY CHARVADEH, SH. BAGHERI, A. MOTA, and M. VALILOO, “EVALUATION OF THE SERUM CONCENTRATIONS OF ALBUMIN AND URIC ACID AS ABIOMARKER IN PATIENTS WITH PARKINSON'S DISEASE,” YAFTEH, vol. 20, no. 3 (77) , pp. 39–47, 2018, [Online]. Available: https://sid.ir/paper/80152/en

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