THE APPLICATION OF A NEW METHOD IN THE TREATMENT OF ALZHEIMER'S DISEASE INDUCED BY STREPTOZOTOCIN IN MALE WISTAR RATS WITH REDUCED HEMATOCRIT EFFECTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ORYAN SHAHRBANOU; NABIUNI MOHAMMAD; BAGHERPOUR ZARCHY MASOUD; NAZARI SERENJE MORTEZA; BAGHERPOUR ZARCHY ALI; SHAHZAMANI KINA

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Yafteh Year:2015 | Volume:17 | Issue:2 (64) Page(s): 105-112

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,224

Download:

Cites:

Information Journal Paper

Title

THE APPLICATION OF A NEW METHOD IN THE TREATMENT OF ALZHEIMER'S DISEASE INDUCED BY STREPTOZOTOCIN IN MALE WISTAR RATS WITH REDUCED HEMATOCRIT EFFECTS

Author(s)

Keywords

ALZHEIMERQ2

ERYTHROPOIETINQ2

HEMATOCRITQ2

Abstract

Background: The ALZHEIMER is a common progressive and degenerative disease which causes dementia and ruin of brain cells especially in Hippocampus region. Recently, it has been appeared that ERYTHROPOIETIN with its neural-protective action causes an improvement in cognitive functions during this disease. This study aims to find an alternative approach instead of traditional intraventricular injection to deliver ERYTHROPOIETIN into the brain without passing the blood-brain barrier.Materials and Methods: In order to induce ALZHEIMER in rats, the STZ was injected in lateral ventricles of brain. Two weeks after ALZHEIMER induction, different doses of ERYTHROPOIETIN were injected in sisternamagna for treatment of the disease with decreased side effects. After the treatment period, all rats were tested by passive avoidence learning test using shuttle box, and measuring of blood HEMATOCRIT.Results: Although the ERYTHROPOIETIN did not have significant influence on improvement of memory and learning phenomena in both control and sham groups, it resulted in a significant difference in improvement of the disease comparing STZ group that this treatment was accompanied with decreased HEMATOCRIT than the group receiving 5000 U/Kg doses.Conclusion: These results suggested that injection of STZ in lateral ventricles of brain contributes to extreme damage in memory and learning similar to ALZHEIMER; on the other hand, ERYTHROPOIETIN prevents such a damage accompanied with decreased HEMATOCRIT.

Cites

No record.

References

No record.

Cite

APA: Copy

ORYAN, SHAHRBANOU, NABIUNI, MOHAMMAD, BAGHERPOUR ZARCHY, MASOUD, NAZARI SERENJE, MORTEZA, BAGHERPOUR ZARCHY, ALI, & SHAHZAMANI, KINA. (2015). THE APPLICATION OF A NEW METHOD IN THE TREATMENT OF ALZHEIMER'S DISEASE INDUCED BY STREPTOZOTOCIN IN MALE WISTAR RATS WITH REDUCED HEMATOCRIT EFFECTS. YAFTEH, 17(2 (64)), 105-112. SID. https://sid.ir/paper/80170/en

Vancouver: Copy

ORYAN SHAHRBANOU, NABIUNI MOHAMMAD, BAGHERPOUR ZARCHY MASOUD, NAZARI SERENJE MORTEZA, BAGHERPOUR ZARCHY ALI, SHAHZAMANI KINA. THE APPLICATION OF A NEW METHOD IN THE TREATMENT OF ALZHEIMER'S DISEASE INDUCED BY STREPTOZOTOCIN IN MALE WISTAR RATS WITH REDUCED HEMATOCRIT EFFECTS. YAFTEH[Internet]. 2015;17(2 (64)):105-112. Available from: https://sid.ir/paper/80170/en

IEEE: Copy

SHAHRBANOU ORYAN, MOHAMMAD NABIUNI, MASOUD BAGHERPOUR ZARCHY, MORTEZA NAZARI SERENJE, ALI BAGHERPOUR ZARCHY, and KINA SHAHZAMANI, “THE APPLICATION OF A NEW METHOD IN THE TREATMENT OF ALZHEIMER'S DISEASE INDUCED BY STREPTOZOTOCIN IN MALE WISTAR RATS WITH REDUCED HEMATOCRIT EFFECTS,” YAFTEH, vol. 17, no. 2 (64), pp. 105–112, 2015, [Online]. Available: https://sid.ir/paper/80170/en

Related Journal Papers