SIMULTANEOUS STUDY ON THE EFFECTS OF JUJUBE ALCOHOL EXTRACT, GALLIC ACID, ANDENDURANCE TRAINING ON HISTOPATHOLOGY CHANGES OF THE HIPPOCAMPUS IN MALERATS WHICH HAD BEEN POISONED BY ANABOLIC STEROIDS

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GHOLAMI T.; AZARBAYJANI M.A.; MATINHOMAEE H.

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Journal: Yafteh Year:2018 | Volume:20 | Issue:2 (76) Page(s): 32-40

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Title

SIMULTANEOUS STUDY ON THE EFFECTS OF JUJUBE ALCOHOL EXTRACT, GALLIC ACID, ANDENDURANCE TRAINING ON HISTOPATHOLOGY CHANGES OF THE HIPPOCAMPUS IN MALERATS WHICH HAD BEEN POISONED BY ANABOLIC STEROIDS

Author(s)

GHOLAMI T. | AZARBAYJANI M.A. | MATINHOMAEE H. | Issue Writer Certificate

Keywords

ANABOLIC STEROIDQ1

HIPPOCAMPUSQ2

JUJUBEQ2

GALLIC ACIDQ2

ENDURANCE TRAININGQ1

Abstract

Background: ANABOLIC STEROID hormones are commonly misued by athletes in order to improveathletic performance. The aim of present research is the simultaneous study of the effect of JUJUBEalcohol extract, GALLIC ACID and ENDURANCE TRAINING on histopathology changes of HIPPOCAMPUS inmale rats, which had been poisoned by ANABOLIC STEROIDs. Materials and Methods: In this research, female wistar rats, weighing from 200-250g wereselected randomly and divided into 10 groups as follows: Group 1-control, group 2-instinct, group3-poisoned by Boldenon (5 mg/kg), group 4-jujube + Boldenon, group 5-Gallic acid+ Boldenon, group 6-Endurance Training + Boldenon (5mil/gr), group 7 JUJUBE plus ENDURANCE TRAINING, group8-Gallic acid plus ENDURANCE TRAINING, group 9 Boldenon (2 mg/kg), group 10 Boldenon 2mg plusendurance training. After 8 weeks of ENDURANCE TRAINING and receiving Boldenon weekly throughmuscular injection, tissue sampling was done on the rats and then a histopathology study wasconducted. Results: The findings show that the structural changes of the HIPPOCAMPUS in all groups incomparison to the control group are significantly higher, but there was no inflammation in anygroup. Based on the results of present study, using Boldenon (high dosage – low dosage) causesstructural changes in HIPPOCAMPUS. Conclusion: Discussion and conclusion: based on the present research, it was found that structuralchanges of HIPPOCAMPUS tissue caused by poisoning by Boldenon in all groups was significantlymore than in the control group. However, in no group, was enlargement seen. It was also shown thatendurance JUJUBE essence, and GALLIC ACID has some effects in decreasing neurological damagecaused by receiving Boldenon and has synergistic effects.

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APA: Copy

GHOLAMI, T., AZARBAYJANI, M.A., & MATINHOMAEE, H.. (2018). SIMULTANEOUS STUDY ON THE EFFECTS OF JUJUBE ALCOHOL EXTRACT, GALLIC ACID, ANDENDURANCE TRAINING ON HISTOPATHOLOGY CHANGES OF THE HIPPOCAMPUS IN MALERATS WHICH HAD BEEN POISONED BY ANABOLIC STEROIDS. YAFTEH, 20(2 (76) ), 32-40. SID. https://sid.ir/paper/80254/en

Vancouver: Copy

GHOLAMI T., AZARBAYJANI M.A., MATINHOMAEE H.. SIMULTANEOUS STUDY ON THE EFFECTS OF JUJUBE ALCOHOL EXTRACT, GALLIC ACID, ANDENDURANCE TRAINING ON HISTOPATHOLOGY CHANGES OF THE HIPPOCAMPUS IN MALERATS WHICH HAD BEEN POISONED BY ANABOLIC STEROIDS. YAFTEH[Internet]. 2018;20(2 (76) ):32-40. Available from: https://sid.ir/paper/80254/en

IEEE: Copy

T. GHOLAMI, M.A. AZARBAYJANI, and H. MATINHOMAEE, “SIMULTANEOUS STUDY ON THE EFFECTS OF JUJUBE ALCOHOL EXTRACT, GALLIC ACID, ANDENDURANCE TRAINING ON HISTOPATHOLOGY CHANGES OF THE HIPPOCAMPUS IN MALERATS WHICH HAD BEEN POISONED BY ANABOLIC STEROIDS,” YAFTEH, vol. 20, no. 2 (76) , pp. 32–40, 2018, [Online]. Available: https://sid.ir/paper/80254/en

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