CYTOTOXICITY EFFECT OF RECOMBINANT OUTER MEMBRANE INFLAMMATORY PROTEIN (OIPA) OF HELICOBACTER PYLORI ON A BREAST CANCER CELL LINE

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SOLEIMANI NEDA; MOHABATI MOBAREZ ASHRAF; TEYMOURNEJAD OMID; BORHANI KATAYOUN

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Journal: Pathobiology Research Year:2014 | Volume:17 | Issue:3 Page(s): 57-66

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Title

CYTOTOXICITY EFFECT OF RECOMBINANT OUTER MEMBRANE INFLAMMATORY PROTEIN (OIPA) OF HELICOBACTER PYLORI ON A BREAST CANCER CELL LINE

Author(s)

SOLEIMANI NEDA | MOHABATI MOBAREZ ASHRAF | TEYMOURNEJAD OMID | BORHANI KATAYOUN | Issue Writer Certificate

Keywords

4T1 CELLQ2

VIABILITYQ1

OUTER INFLAMMATORY PROTEIN AQ2

BREAST CANCERQ2

Abstract

Objective: BREAST CANCER is one of the leading causes of death in women worldwide. Conventional treatments use cytotoxic drugs which have high numbers of side effects. Currently pharmacologists are searching for novel drugs with fewer side effects and maximum efficiency as BREAST CANCER treatment. The aim of the current study is to clarify the cytotoxicity effect of the recombinantouter membrane inflammatory protein (oipA) of Helicobacter pylori (H. pylori)on a BREAST CANCER cell line.Methods: We purified recombinant H. pylori oipA by Ni–NTA affinity chromatography. BREAST CANCER cells (4T1) were treated with different concentrations of recombinant oipA for various lengths of time. Cell VIABILITY was evaluated by the VIABILITY assay (MTT test).Results: SDS-PAGE analysis showed the expression of an approximately 34000 dalton protein. Statistical analysis showed oipA toxic effects on 4T1 CELLs at a concentration of 250 mg/ml after 24 h.Conclusion: These findings suggested that oipA had a direct toxic effect on a BREAST CANCER cell line (4T1) in vitro. The oipA protein might be a new tool for future therapeutic strategies in cancer immunotherapy.

Cites

THE ROLE OF HLICOBACTER PYLORI IN GASTRIC CANCER AND ITS CLINICAL APPLICATIONS IN CANCER TREATMENT

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APA: Copy

SOLEIMANI, NEDA, MOHABATI MOBAREZ, ASHRAF, TEYMOURNEJAD, OMID, & BORHANI, KATAYOUN. (2014). CYTOTOXICITY EFFECT OF RECOMBINANT OUTER MEMBRANE INFLAMMATORY PROTEIN (OIPA) OF HELICOBACTER PYLORI ON A BREAST CANCER CELL LINE. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 17(3), 57-66. SID. https://sid.ir/paper/80979/en

Vancouver: Copy

SOLEIMANI NEDA, MOHABATI MOBAREZ ASHRAF, TEYMOURNEJAD OMID, BORHANI KATAYOUN. CYTOTOXICITY EFFECT OF RECOMBINANT OUTER MEMBRANE INFLAMMATORY PROTEIN (OIPA) OF HELICOBACTER PYLORI ON A BREAST CANCER CELL LINE. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2014;17(3):57-66. Available from: https://sid.ir/paper/80979/en

IEEE: Copy

NEDA SOLEIMANI, ASHRAF MOHABATI MOBAREZ, OMID TEYMOURNEJAD, and KATAYOUN BORHANI, “CYTOTOXICITY EFFECT OF RECOMBINANT OUTER MEMBRANE INFLAMMATORY PROTEIN (OIPA) OF HELICOBACTER PYLORI ON A BREAST CANCER CELL LINE,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 17, no. 3, pp. 57–66, 2014, [Online]. Available: https://sid.ir/paper/80979/en

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