STUDY OF THE EXPRESSIONS OF IL-20R1 AND IL-20R2 IN C57BL/6 MICE ASTROGLIAL CELLS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ABD NIKFARJAM BAHAREH; EBTEKAR MASSOUMEH; SABOUNI FARZANEH; POURPAK ZAHRA; KHEIRANDISH MARYAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Pathobiology Research Year:2013 | Volume:15 | Issue:4 Page(s): 35-47

Download Full-Text

Persian Verion

View:

1,200

Download:

Cites:

Information Journal Paper

Title

STUDY OF THE EXPRESSIONS OF IL-20R1 AND IL-20R2 IN C57BL/6 MICE ASTROGLIAL CELLS

Author(s)

Keywords

ASTROCYTESQ2

LIPOPOLYSACCHARIDEQ2

IL-20R1Q2

IL-20R2Q2

Abstract

Objective: ASTROCYTES are the most abundant glial cell type. They may promote or inhibit CNS inflammation depending on which cytokines are secreted. ASTROCYTES also have immune roles. IL-19, IL-20, and IL-24 activate a heterodimer receptor composed of the IL-20R1 a-chain and the IL-20R2 b-chain. It has long been considered that signaling by these receptor complexes affects immunological reactions, however the biological functions of IL-20R1 and IL-20R2 in the brain remain unclear. As the first step to address the role of these cytokine receptors in the brain, in this study we have researched the expressions of IL-20R1 and IL-20R2 in C57BL/6 mice ASTROCYTES.Methods: We examined expressions of IL-20R1 and IL-20R2 proteins in mice astroglial cells and in the 1321N1 astrocytoma cell line in response to MOG, LPS and GM-CSF by flow cytometry. The effect of LPS on mRNA expression of IL-20R1 and IL-20R2 was investigated by RT-PCR.Results: We provide, for the first time, evidence that ASTROCYTES expressed IL-20R1 and IL-20R2 mRNA not only in response to LPS stimulation but also in unstimulated ASTROCYTES. We did not observe the expressions of IL-20R1 and IL-20R2 proteins in mice astroglial cells and the 1321N1 astrocytoma cell line.Conclusions: IL-20R1 and IL-20R2 mRNA are constitutively expressed in ASTROCYTES. Because the majority of neuropathological processes involve ASTROCYTES and inflammatory cytokines, the results of this study, which are reported for the first time, have important implications for future research.

Cites

No record.

References

No record.

Cite

APA: Copy

ABD NIKFARJAM, BAHAREH, EBTEKAR, MASSOUMEH, SABOUNI, FARZANEH, POURPAK, ZAHRA, & KHEIRANDISH, MARYAM. (2013). STUDY OF THE EXPRESSIONS OF IL-20R1 AND IL-20R2 IN C57BL/6 MICE ASTROGLIAL CELLS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 15(4), 35-47. SID. https://sid.ir/paper/81001/en

Vancouver: Copy

ABD NIKFARJAM BAHAREH, EBTEKAR MASSOUMEH, SABOUNI FARZANEH, POURPAK ZAHRA, KHEIRANDISH MARYAM. STUDY OF THE EXPRESSIONS OF IL-20R1 AND IL-20R2 IN C57BL/6 MICE ASTROGLIAL CELLS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2013;15(4):35-47. Available from: https://sid.ir/paper/81001/en

IEEE: Copy

BAHAREH ABD NIKFARJAM, MASSOUMEH EBTEKAR, FARZANEH SABOUNI, ZAHRA POURPAK, and MARYAM KHEIRANDISH, “STUDY OF THE EXPRESSIONS OF IL-20R1 AND IL-20R2 IN C57BL/6 MICE ASTROGLIAL CELLS,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 15, no. 4, pp. 35–47, 2013, [Online]. Available: https://sid.ir/paper/81001/en

Related Journal Papers