INVESTIGATION OF THE E-CADHERIN PROMOTER METHYLATION IN PATIENTS WITH COLORECTAL CANCER IN IRAN

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MOHAMMAD GANJI SHAHLA; SAMEI ELHAM; HASHEMI AHMAD; REZAGHOLIZADEH AMIR; KAZEMNEJAD ANOOSHIRVAN; MOSTAKHDEMIN HOSSEINI ZAHRA

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Journal: Pathobiology Research Year:2013 | Volume:16 | Issue:2 Page(s): 75-83

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Title

INVESTIGATION OF THE E-CADHERIN PROMOTER METHYLATION IN PATIENTS WITH COLORECTAL CANCER IN IRAN

Author(s)

Keywords

E-CADHERIN PROMOTERQ2

METHYLATIONQ2

EPIGENETICQ2

COLORECTAL CANCERQ2

Abstract

Objective: E-cadherin is widely down-regulated and tightly associated with tumor invasion and metastasis in multiple human cancer types. Recent studies have shown that aberrant METHYLATION of the E-cadherin gene promoter contributes to its silencing.However, information regarding EPIGENETIC inactivation of E-cadherin in COLORECTAL CANCER is insufficient. Herein, we correlate association of the METHYLATION of the ECadherin promoter with pathological features of COLORECTAL CANCER as well as history and demographic data.Methods: We used METHYLATION specific polymerase chain reaction (MSPCR) to examine METHYLATION status of the 5’ CpG island of E-cadherin along with its expression by using RT-PCR following surgical resection of 66 unrelated patients with COLORECTAL CANCER.Results: Results showed that 35 out of 66 tumor DNA samples (53%) showed aberrant METHYLATIONs. In contrast, all normal tissues were unmethylated.Conclusion: The obtained results show a similarity with the Japanese (54.5%) and Greek (55.7%) populations. The results have confirmed METHYLATION of this gene in sporadic COLORECTAL CANCER cases (40.8%) in the Iranian population by researchers in Shiraz. These data suggest that EPIGENETIC silencing via aberrant METHYLATION of the E-CADHERIN PROMOTER plays a critical role in the inactivation of this tumor suppressor gene in COLORECTAL CANCER.

Cites

DNA METHYLATION IN EXON 1 OF CDKN2A GENE IN FORMALIN-FIXED, PARAFFIN-EMBEDDED COLON CANCER SAMPLES

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APA: Copy

MOHAMMAD GANJI, SHAHLA, SAMEI, ELHAM, HASHEMI, AHMAD, REZAGHOLIZADEH, AMIR, KAZEMNEJAD, ANOOSHIRVAN, & MOSTAKHDEMIN HOSSEINI, ZAHRA. (2013). INVESTIGATION OF THE E-CADHERIN PROMOTER METHYLATION IN PATIENTS WITH COLORECTAL CANCER IN IRAN. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 16(2), 75-83. SID. https://sid.ir/paper/81008/en

Vancouver: Copy

MOHAMMAD GANJI SHAHLA, SAMEI ELHAM, HASHEMI AHMAD, REZAGHOLIZADEH AMIR, KAZEMNEJAD ANOOSHIRVAN, MOSTAKHDEMIN HOSSEINI ZAHRA. INVESTIGATION OF THE E-CADHERIN PROMOTER METHYLATION IN PATIENTS WITH COLORECTAL CANCER IN IRAN. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2013;16(2):75-83. Available from: https://sid.ir/paper/81008/en

IEEE: Copy

SHAHLA MOHAMMAD GANJI, ELHAM SAMEI, AHMAD HASHEMI, AMIR REZAGHOLIZADEH, ANOOSHIRVAN KAZEMNEJAD, and ZAHRA MOSTAKHDEMIN HOSSEINI, “INVESTIGATION OF THE E-CADHERIN PROMOTER METHYLATION IN PATIENTS WITH COLORECTAL CANCER IN IRAN,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 16, no. 2, pp. 75–83, 2013, [Online]. Available: https://sid.ir/paper/81008/en

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