SUPPRESSIVE EFFECT OF LACTOBACILLUS ACIDOPHILUS ON ANTIBIOTIC RESISTANT H.PYLORI STRAINS ISOLATED FROM GASTRIC PATIENTS

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HAGHI TOMATARI F.; MOHABATI MOBAREZ A.; AMINI MOHSEN; HOSSEINIDOUST S.R.

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Journal: Pathobiology Research Year:2007 | Volume:10 | Issue:1 Page(s): 43-49

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Title

SUPPRESSIVE EFFECT OF LACTOBACILLUS ACIDOPHILUS ON ANTIBIOTIC RESISTANT H.PYLORI STRAINS ISOLATED FROM GASTRIC PATIENTS

Author(s)

HAGHI TOMATARI F. | MOHABATI MOBAREZ A. | AMINI MOHSEN | HOSSEINIDOUST S.R. | Issue Writer Certificate

Keywords

HELICOBACTER PYLORIQ2

LACTOBACILLUS ACIDOPHILUSQ3

ANTIBIOTIC RESISTANCEQ2

SUPPRESSIVE EFFECTQ3

GASTRIC BIOPSYQ2

PROBIOTICQ2

Abstract

Objective: Current of antibiotic treatment for Hpylori infection is often associated with frequent adverse effect and resistant to antibiotic. Alternative treatment method to control Hpylori infection is needed. The aim of this study was to test in vitro anti Helicobacter activity of Lactobacilli acidophilus isolated from yogurt.Material and Methods: Forty Hpylori strains isolated from 145 human gastric biopsies. After the primary culture of biopsies in the brucella brucella agar and identification of Hpylori by biochemical tests, susceptibility tests to antibiotics (metronidazole, clarithromycin, amoxicillin and tetracycline) were performed with MDDM (Modified Disk Diffusion Method) and E test. The isolates were cultured in brucella broth and the effect of LACTOBACILLUS ACIDOPHILUS isolated from yogurt (cultured in MRS broth) on growth of Hpylori was tested by a mixed culture technique (co-culture).Results: Twenty five (62.5%) of the 40 H.pylori isolates were resistant to antibiotics. Resistance rates to metronidazole, clarithromycin, amoxicillin and tetracycline were 62.5%, 22.5%, 2.5% and 0% respectively. Twenty two (56%) of the 40 H.pylori isolates were inhibited by L. acidophilus in mixed culture. This inhibition occurred only when the two organisms were incubated together for more than 24 h. LACTOBACILLUS ACIDOPHILUS was able to inhibit the growth of both antibiotic sensitive and resistant H.pylori strains. Fifteen (68.2%) of the inhibited isolates were susceptible to antibiotics and seven (31.8%) were resistant to antibiotics.Conclusion: We observed a significant suppression in the growth of Hpylori in the presence of L. acidophilus. This occurred only when the two organisms were incubated together for more than 24h. Based on our findings, L. acidophilus was found to be a potentially effective PROBIOTICs against Hpylori and could enhance antibiotic therapy fur H.pylori eradication in humans.

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APA: Copy

HAGHI TOMATARI, F., MOHABATI MOBAREZ, A., AMINI, MOHSEN, & HOSSEINIDOUST, S.R.. (2007). SUPPRESSIVE EFFECT OF LACTOBACILLUS ACIDOPHILUS ON ANTIBIOTIC RESISTANT H.PYLORI STRAINS ISOLATED FROM GASTRIC PATIENTS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 10(1), 43-49. SID. https://sid.ir/paper/81042/en

Vancouver: Copy

HAGHI TOMATARI F., MOHABATI MOBAREZ A., AMINI MOHSEN, HOSSEINIDOUST S.R.. SUPPRESSIVE EFFECT OF LACTOBACILLUS ACIDOPHILUS ON ANTIBIOTIC RESISTANT H.PYLORI STRAINS ISOLATED FROM GASTRIC PATIENTS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2007;10(1):43-49. Available from: https://sid.ir/paper/81042/en

IEEE: Copy

F. HAGHI TOMATARI, A. MOHABATI MOBAREZ, MOHSEN AMINI, and S.R. HOSSEINIDOUST, “SUPPRESSIVE EFFECT OF LACTOBACILLUS ACIDOPHILUS ON ANTIBIOTIC RESISTANT H.PYLORI STRAINS ISOLATED FROM GASTRIC PATIENTS,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 10, no. 1, pp. 43–49, 2007, [Online]. Available: https://sid.ir/paper/81042/en

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