QUANTITATIVE EVALUATION OF IMATIB EFFLUX AND INFLUX TRANSPORTERS EXPRESSION IN CHRONIC MYELOID LEUKEMIA (CML) PATIENTS

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SOLALI SAEID; KAVIANI SAEID; MOVASSAGHPUOR ALI AKBAR; ALI PARASTI MOHAMMAD REZA; SOLEIMANI MASOUD; NORUZINIA MEHRDAD; ABROUN SAEID; KAVIANI ZEINAB

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Journal: Pathobiology Research Year:2011 | Volume:14 | Issue:1 Page(s): 49-57

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Title

QUANTITATIVE EVALUATION OF IMATIB EFFLUX AND INFLUX TRANSPORTERS EXPRESSION IN CHRONIC MYELOID LEUKEMIA (CML) PATIENTS

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Keywords

CMLQ3

MDR1Q2

HOCT1Q2

GENE EXPRESSIONQ2

REAL-TIME PCRQ2

Abstract

Objective: In this study quantitative expression of MDR1 and HOCT1 genes in CML patients and normal people were measured using REAL-TIME PCR.Materials and Methods: To study quantitative expression of these genes by REAL-TIME PCR, master-mix with syber green was used. Peripheral blood samples from 30 CML patients and 27 normal persons were harvested. REAL-TIME PCR results were analyzed with relative quantification method.Result: This study showed that in the patients group who were under treatment with Imatib, MDR1 GENE EXPRESSION was increased which was statistically significant. This increase has a direct relation with disease progress. GENE EXPRESSION in AP and BP patients was also higher than CP patients. In contrast, HOCT1 expression in patients group in comparison with normal group was not statistically significant.Conclusion: MDR1 increase in leukemic cell membrane results in the reduction of intra-cellular drug concentration. Thus, optimal concentration of drug for inhibition of BCR-ABL tyrosine kinase is not achieved which culminated in disease progression to AP and BP phases. Moreover changes in HOCT1 GENE EXPRESSION as an influx transporter of Imatib could affect intracellular concentration of drug and finally determine therapy outcome. However, in this study HOCT1 GENE EXPRESSION was variable and was not statistically significant.

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APA: Copy

SOLALI, SAEID, KAVIANI, SAEID, MOVASSAGHPUOR, ALI AKBAR, ALI PARASTI, MOHAMMAD REZA, SOLEIMANI, MASOUD, NORUZINIA, MEHRDAD, ABROUN, SAEID, & KAVIANI, ZEINAB. (2011). QUANTITATIVE EVALUATION OF IMATIB EFFLUX AND INFLUX TRANSPORTERS EXPRESSION IN CHRONIC MYELOID LEUKEMIA (CML) PATIENTS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 14(1), 49-57. SID. https://sid.ir/paper/81115/en

Vancouver: Copy

SOLALI SAEID, KAVIANI SAEID, MOVASSAGHPUOR ALI AKBAR, ALI PARASTI MOHAMMAD REZA, SOLEIMANI MASOUD, NORUZINIA MEHRDAD, ABROUN SAEID, KAVIANI ZEINAB. QUANTITATIVE EVALUATION OF IMATIB EFFLUX AND INFLUX TRANSPORTERS EXPRESSION IN CHRONIC MYELOID LEUKEMIA (CML) PATIENTS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2011;14(1):49-57. Available from: https://sid.ir/paper/81115/en

IEEE: Copy

SAEID SOLALI, SAEID KAVIANI, ALI AKBAR MOVASSAGHPUOR, MOHAMMAD REZA ALI PARASTI, MASOUD SOLEIMANI, MEHRDAD NORUZINIA, SAEID ABROUN, and ZEINAB KAVIANI, “QUANTITATIVE EVALUATION OF IMATIB EFFLUX AND INFLUX TRANSPORTERS EXPRESSION IN CHRONIC MYELOID LEUKEMIA (CML) PATIENTS,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 14, no. 1, pp. 49–57, 2011, [Online]. Available: https://sid.ir/paper/81115/en

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