EVALUATION OF RED CELL ALLOANTIBODIES IN PATIENTS WITH THALASSEMIA IN KERMAN

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FARSINEZHD A.R.; POURFATH ELAH A.A.

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Journal: Pathobiology Research Year:2002 | Volume:5 | Issue:1 Page(s): 93-99

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Title

EVALUATION OF RED CELL ALLOANTIBODIES IN PATIENTS WITH THALASSEMIA IN KERMAN

Author(s)

FARSINEZHD A.R. | POURFATH ELAH A.A. | Issue Writer Certificate

Keywords

THALASSEMIAQ4

ALLOANTIBODYQ3

TRANSFUSIONQ3

BLOOD GROUPSQ4

Abstract

Purpose: The development of hemolytic alloantibodies and erythrocyte autoantibodies complicates TRANSFUSION therapy in thalassemic patients .This research has been carried out to determine and identify red cell alloantibodies in multitransfused patients with THALASSEMIA.Materials and Methods: Three hundred patients were studied with 11.3% of them being under 6, 63.7% between 6 and 15, and 25 percent over 15 years old. All of the patients received blood matched for the ABO system and Rh-D antigen.Results and Discussion: Twenty seven patients had red cell antibodies (9%). From the 27 patients who had ALLOANTIBODY, 14 had one antibody (51.9%), 9 had two antibodies (33.3%) and 4 had three antibodies (14.8%). A total of 44 alloantibadies were found in these patients from which twenty one antibodies belonged to the Rh system (47.7%), 15 to Kell (34.1%), 4 to MNSs (9.1%),3 to Kidd (6.8%) and 1 to DuffY system (2.3%). In patients whose blood TRANSFUSION had started after the age of 3, the percentage of patients with alloantibodies was higher than those whose TRANSFUSION started before the age of 3 (15.1% VS. 4%, P<0.05). There was no signifcant relation between the age and sex of the patients and the existance of ALLOANTIBODY and also between the number of TRANSFUSIONs and the existance of ALLOANTIBODY in the patients serum. Alloimmunization causes common serious complications in major thalassemi. patients, who are affected by donor-recipient RBC antigen mismatch and immunological factors.

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APA: Copy

FARSINEZHD, A.R., & POURFATH ELAH, A.A.. (2002). EVALUATION OF RED CELL ALLOANTIBODIES IN PATIENTS WITH THALASSEMIA IN KERMAN. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 5(1), 93-99. SID. https://sid.ir/paper/81191/en

Vancouver: Copy

FARSINEZHD A.R., POURFATH ELAH A.A.. EVALUATION OF RED CELL ALLOANTIBODIES IN PATIENTS WITH THALASSEMIA IN KERMAN. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2002;5(1):93-99. Available from: https://sid.ir/paper/81191/en

IEEE: Copy

A.R. FARSINEZHD, and A.A. POURFATH ELAH, “EVALUATION OF RED CELL ALLOANTIBODIES IN PATIENTS WITH THALASSEMIA IN KERMAN,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 5, no. 1, pp. 93–99, 2002, [Online]. Available: https://sid.ir/paper/81191/en

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