IN VITRO EVALUATION OF EFFICACY AND TOXICITY OF AMPHOTERICIN B-LOADED NANOCAPSULES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ASGHARI H.M.; GHARIB A.; FAEZIZADEH Z.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Pathobiology Research Year:2010 | Volume:13 | Issue:3 Page(s): 1-10

Download Full-Text

Persian Verion

View:

1,046

Download:

Cites:

Information Journal Paper

Title

IN VITRO EVALUATION OF EFFICACY AND TOXICITY OF AMPHOTERICIN B-LOADED NANOCAPSULES

Author(s)

ASGHARI H.M. | GHARIB A. | FAEZIZADEH Z. | Issue Writer Certificate

Keywords

AMPHOTRICIN BQ2

NANOCAPSULEQ3

CANDIDA ALBICANSQ3

ENTRAPMENT EFFICACYQ3

Abstract

Objective: Amphotericin B (AmB) is an ancient antifungal drug and proper for treatment of systemic fungal infection. Unfortunately, this antibiotic has shown some side effects such as nephrotoxicity. Therefore, recently new AmB formulated has been prepared for reduced toxicity and increased effectiveness.Materials and Methods: AmB NANOCAPSULEs prepared from polymers such as poly D, L-lactide-co-glycolide by means of a solvent displacement technique. Then, the dried NANOCAPSULEs prepared by using SiO2 and ENTRAPMENT EFFICACY of AmB were measured by spectrophotometry technique. The MICs of these NANOCAPSULEs to CANDIDA ALBICANS (ATCC 90028) was also determined by using microdilution method. Then, in vitro toxicity (haemolysis) of the AmB- loaded NANOCAPSULEs determined on human red blood cells.Results: The data shows AmB ENTRAPMENT EFFICACY for NANOCAPSULEs were 75%±0.13. The MICs of AmB-loaded NANOCAPSULEs against C. albicans tested were significantly reduced compared to that of free antibiotic. Also, the AmB-loaded NANOCAPSULEs found to be 5.89 times less toxic than free AmB on human red blood cells.Conclusion: The results suggest that prepared AmB-loaded NANOCAPSULEs in this research may be an appropriate delivery system for AmB to be used in the treatment of fungal infections.

Cites

No record.

References

Cite

APA: Copy

ASGHARI, H.M., GHARIB, A., & FAEZIZADEH, Z.. (2010). IN VITRO EVALUATION OF EFFICACY AND TOXICITY OF AMPHOTERICIN B-LOADED NANOCAPSULES. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 13(3), 1-10. SID. https://sid.ir/paper/81213/en

Vancouver: Copy

ASGHARI H.M., GHARIB A., FAEZIZADEH Z.. IN VITRO EVALUATION OF EFFICACY AND TOXICITY OF AMPHOTERICIN B-LOADED NANOCAPSULES. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2010;13(3):1-10. Available from: https://sid.ir/paper/81213/en

IEEE: Copy

H.M. ASGHARI, A. GHARIB, and Z. FAEZIZADEH, “IN VITRO EVALUATION OF EFFICACY AND TOXICITY OF AMPHOTERICIN B-LOADED NANOCAPSULES,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 13, no. 3, pp. 1–10, 2010, [Online]. Available: https://sid.ir/paper/81213/en

Related Journal Papers