EVALUATION OF CR (VI) INDUCED NEUROTOXICITY AND OXIDATIVE STRESS IN PC12 CELLS

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DASHTI ABOLFAZL; SOODI MALIHEH; AMANI NAHID

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Journal: Pathobiology Research Year:2015 | Volume:18 | Issue:1 Page(s): 55-65

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Title

EVALUATION OF CR (VI) INDUCED NEUROTOXICITY AND OXIDATIVE STRESS IN PC12 CELLS

Author(s)

DASHTI ABOLFAZL | SOODI MALIHEH | AMANI NAHID | Issue Writer Certificate

Keywords

CR (VI)Q2

NEUROTOXICITYQ2

OXIDATIVE STRESSQ2

Abstract

Objective: Hexavalent chromium [Cr (VI)] compounds are well-known environmental contaminants generated from industrial processes. Several studies have reported the harmful effects of Cr (VI) on different organs, however, little is known about neurotoxic effects of Cr (VI). The aim of this study is to investigate the toxic effects of Cr (VI) on PC12 cells.Methods: PC12 cells were cultured following standard protocol and exposed to various concentrations (1-100 mM) of potassium dichromate (K2Cr2O7) for 24, 48 and 72 h. After exposure, cell viability was measured by the MTT assy. Also following exposure, production of reactive oxygen species (ROS) and lipid peroxidation were measured.Results: Potassium dichromate induced significant cell death in PC12 cells. The IC50 values for cytotoxicity were 22.02 for 24 h, 1.88 for 48 h, and 1.85 for 72 h of exposure.Significant differences between IC50 for 24 h of exposure compared to 48 and 72 h of exposure were observed (p<0.05). ROS production and lipid peroxidation significantly increased in the Cr (VI) treated groups compared to the control group (p<0.05).Conclusion: The results indicated that Cr (VI) induced dose and time dependent cytotoxicity in PC12 cells which indicated neurotoxic effects of Cr (VI). Mechanisms of Cr (VI) induced toxicity have not been fully determined, however increased production of ROS and lipid peroxidation in Cr (VI) treated groups demonstrated that OXIDATIVE STRESS might be involved in NEUROTOXICITY of Cr (VI).

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APA: Copy

DASHTI, ABOLFAZL, SOODI, MALIHEH, & AMANI, NAHID. (2015). EVALUATION OF CR (VI) INDUCED NEUROTOXICITY AND OXIDATIVE STRESS IN PC12 CELLS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 18(1), 55-65. SID. https://sid.ir/paper/81303/en

Vancouver: Copy

DASHTI ABOLFAZL, SOODI MALIHEH, AMANI NAHID. EVALUATION OF CR (VI) INDUCED NEUROTOXICITY AND OXIDATIVE STRESS IN PC12 CELLS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2015;18(1):55-65. Available from: https://sid.ir/paper/81303/en

IEEE: Copy

ABOLFAZL DASHTI, MALIHEH SOODI, and NAHID AMANI, “EVALUATION OF CR (VI) INDUCED NEUROTOXICITY AND OXIDATIVE STRESS IN PC12 CELLS,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 18, no. 1, pp. 55–65, 2015, [Online]. Available: https://sid.ir/paper/81303/en

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