PROTECTIVE EFFECT OF EDARAVONE AGAINST NEPHROTOXICITY AND NEUROTOXICITY OF ACUTE EXPOSURE TO DIAZINON

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VAHIDIRAD MILAD; ARAB NOZARI MILAD; MOHAMMADI HAMIDREZA; SHAKI FATEMEH

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:165 Page(s): 175-182

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Title

PROTECTIVE EFFECT OF EDARAVONE AGAINST NEPHROTOXICITY AND NEUROTOXICITY OF ACUTE EXPOSURE TO DIAZINON

Author(s)

VAHIDIRAD MILAD | ARAB NOZARI MILAD | MOHAMMADI HAMIDREZA | SHAKI FATEMEH | Issue Writer Certificate

Keywords

DIAZINONQ2

EDARAVONEQ1

NEPHROTOXICITYQ2

NEUROTOXICITYQ3

OXIDATIVE STRESSQ2

Abstract

Background and purpose: DIAZINON (Dz) is a widely used insecticide. It can causenephrotoxicity and NEUROTOXICITY by induction of OXIDATIVE STRESS. EDARAVONE is a drug with antioxidanteffect that is used in treatment of acute infraction disorders. In this study we used EDARAVONE forameliorating DIAZINON induced kidney and brain damage. Materials and methods: Twenty four male Wistar rats were divided into the following groups: Control (normal saline), Dz (150mg/kg) and EDARAVONE (10mg/kg and 20mg/kg) that were injected 30minbefore Dz. After 24 hr, the animals were anesthetized and the brain and kidney tissues were separated. Then OXIDATIVE STRESS factors were evaluated. Blood serum samples were also taken to determine thelevels of BUN, creatinine, and nitric oxide. Results: Dz significantly increased OXIDATIVE STRESS markers such as reactive oxygen species(ROS), lipid peroxidation, protein carbonyl, and glutathione oxidation in kidney and brain tissues. Also, the levels of BUN, creatinine and nitric oxide increased after Dz injection. Interestingly, ederavoneadministration significantly decreased ROS production in rats’ kidney and brain tissues (p<0. 05). It alsosignificantly protected kidney and brain against lipid peroxidation and glutathione oxidation (p<0. 05). EDARAVONE treatment could noticeably inhibit DIAZINON induced protein carbonyl production in bothtissues. Furthermore, EDARAVONE significantly ameliorated the increased levels of BUN, creatinine, andnitric oxide due to Dz administration (p<0. 05). Conclusion: These data suggested that EDARAVONE can prevent NEPHROTOXICITY, NEUROTOXICITY andacute toxicity of DIAZINON via reducing OXIDATIVE STRESS.

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APA: Copy

VAHIDIRAD, MILAD, ARAB NOZARI, MILAD, MOHAMMADI, HAMIDREZA, & SHAKI, FATEMEH. (2018). PROTECTIVE EFFECT OF EDARAVONE AGAINST NEPHROTOXICITY AND NEUROTOXICITY OF ACUTE EXPOSURE TO DIAZINON. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(165 ), 175-182. SID. https://sid.ir/paper/45356/en

Vancouver: Copy

VAHIDIRAD MILAD, ARAB NOZARI MILAD, MOHAMMADI HAMIDREZA, SHAKI FATEMEH. PROTECTIVE EFFECT OF EDARAVONE AGAINST NEPHROTOXICITY AND NEUROTOXICITY OF ACUTE EXPOSURE TO DIAZINON. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(165 ):175-182. Available from: https://sid.ir/paper/45356/en

IEEE: Copy

MILAD VAHIDIRAD, MILAD ARAB NOZARI, HAMIDREZA MOHAMMADI, and FATEMEH SHAKI, “PROTECTIVE EFFECT OF EDARAVONE AGAINST NEPHROTOXICITY AND NEUROTOXICITY OF ACUTE EXPOSURE TO DIAZINON,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 165 , pp. 175–182, 2018, [Online]. Available: https://sid.ir/paper/45356/en

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