THE EFFECT OF CRATAEGUS SPP BRANCHLET FEEDING ON ENDOTHELIUMDEPENDENT CONTRACTILE AND RELAXATORY RESPONSE OF THORACIC AORTA FROM DIABETIC RATS

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ROUGHANI M.; BALUCHNEJADMOJARAD TOURANDOKHT; ROUGHANI DEHKORDI F.

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Journal: Pathobiology Research Year:2009 | Volume:12 | Issue:2 Page(s): 61-71

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Title

THE EFFECT OF CRATAEGUS SPP BRANCHLET FEEDING ON ENDOTHELIUMDEPENDENT CONTRACTILE AND RELAXATORY RESPONSE OF THORACIC AORTA FROM DIABETIC RATS

Author(s)

ROUGHANI M. | BALUCHNEJADMOJARAD TOURANDOKHT | ROUGHANI DEHKORDI F. | Issue Writer Certificate

Keywords

CRATAEGUS SPPQ3

DIABETES MELLITUSQ4

ENDOTHELIUMQ3

AORTAQ3

CONTRACTILE RESPONSEQ3

Abstract

Objective: DIABETES MELLITUS is accompanied with higher incidence of cardiovascular disorders. There is some evidence on antidiabetic and cardiovascular improving potential of CRATAEGUS SPP (CS). Thus, the ENDOTHELIUM-dependent effect of oral administration of CS branchlet for 6 weeks on contractile and relaxatory response of thoracic AORTA from diabetic rats was investigated.Materials and Methods: Male Wistar rats were divided into control, CS-treated control, diabetic, CStreated diabetic, and glibenclamide-treated diabetic groups. Treated groups received CS-mixed pelleted food at a weight ratio of 6.25%. Body weight and serum glucose level was measured before the study and at weeks 3 and 6. At the end of study, contractile reactivity of thoracic aortic rings to KCl and phenylephrine and relaxatory response to acetylcholine and sodium nitroprusside was determined using isolated tissue setup.Results: Serum glucose level significantly decreased in CS-treated diabetic group (p<0.01) versus untreated diabetics. In addition, ENDOTHELIUM-intact CS-treated diabetic group showed a significantly lower contraction to KCl and phenylephrine (p<0.05) as compared to diabetic group and ENDOTHELIUM removal abolished this response. Meanwhile, relaxation response of ENDOTHELIUM-intact rings to acetylcholine was significantly higher in CS-treated diabetic group as compared to diabetics (p<0.05). In addition, there were no significant changes amongst the groups regarding relaxatory response to sodium nitroprusside.Conclusion: Chronic oral administration of CS through affecting endothelial-related agents could decrease CONTRACTILE RESPONSE and enhance relaxatory response in aortic tissue of diabetic rat and this may be beneficial in prevention of long-term vascular complications of diabetes.

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APA: Copy

ROUGHANI, M., BALUCHNEJADMOJARAD, TOURANDOKHT, & ROUGHANI DEHKORDI, F.. (2009). THE EFFECT OF CRATAEGUS SPP BRANCHLET FEEDING ON ENDOTHELIUMDEPENDENT CONTRACTILE AND RELAXATORY RESPONSE OF THORACIC AORTA FROM DIABETIC RATS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 12(2), 61-71. SID. https://sid.ir/paper/81311/en

Vancouver: Copy

ROUGHANI M., BALUCHNEJADMOJARAD TOURANDOKHT, ROUGHANI DEHKORDI F.. THE EFFECT OF CRATAEGUS SPP BRANCHLET FEEDING ON ENDOTHELIUMDEPENDENT CONTRACTILE AND RELAXATORY RESPONSE OF THORACIC AORTA FROM DIABETIC RATS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2009;12(2):61-71. Available from: https://sid.ir/paper/81311/en

IEEE: Copy

M. ROUGHANI, TOURANDOKHT BALUCHNEJADMOJARAD, and F. ROUGHANI DEHKORDI, “THE EFFECT OF CRATAEGUS SPP BRANCHLET FEEDING ON ENDOTHELIUMDEPENDENT CONTRACTILE AND RELAXATORY RESPONSE OF THORACIC AORTA FROM DIABETIC RATS,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 12, no. 2, pp. 61–71, 2009, [Online]. Available: https://sid.ir/paper/81311/en

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