EFFECT OF ORAL FEEDING OF ALLIUM ASCALONICUM L. ON THORACIC AORTA CONTRACTILE RESPONSE IN DIABETIC RATS

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FALAHI FARAMARZ; ROUGHANI M.; BAGHERI ALI

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Journal: Koomesh Year:2009 | Volume:10 | Issue:3 (31) Page(s): 213-218

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Title

EFFECT OF ORAL FEEDING OF ALLIUM ASCALONICUM L. ON THORACIC AORTA CONTRACTILE RESPONSE IN DIABETIC RATS

Author(s)

FALAHI FARAMARZ | ROUGHANI M. | BAGHERI ALI | Issue Writer Certificate

Keywords

ALLIUM ASCALONICUM L.Q3

AORTAQ3

DIABETES MELLITUSQ3

CONTRACTILE RESPONSEQ3

Abstract

Introduction: DIABETES MELLITUS is accompanied with higher incidence of cardiovascular disorders. There is some evidence on antidiabetic potential of ALLIUM ASCALONICUM L. (AA). Therefore, this study was conducted to evaluate the beneficial effect of oral two-month administration of AA on contractile reactivity of isolated thoracic AORTA from diabetic rats.Materials and Methods: Male Wistar rats were divided into control, AA-treated control, diabetic, and AA-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was intraperitoneally administered (60 mg/Kg). Meanwhile, treated groups received AA mixed with standard pelleted food at a weight ratio of 6.25% for 2 months. Serum glucose level was measured in weeks 4 and 8. Also after 2 months contractile reactivity of thoracic aortic rings to KCl and noradrenaline was determined using isolated tissue setup.Results: Serum glucose level showed a significant increase in diabetic animals (p<0.001) and this was significantly attenuated in AA-treated diabetic group (p<0.005). In addition, AA-treated diabetic group showed a lower contraction to KCl and noreadrenaline (p<0.05) as compared to diabetic group. Meanwhile, there was no significant difference between control and AA-treated control groups regarding contractile reactivity.Conclusion: Oral administration of AA for 2 months could improve hyperglycemia and also attenuate the contractile responsiveness of the vascular system and this may prevent the development of hypertension in diabetic rats.

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APA: Copy

FALAHI, FARAMARZ, ROUGHANI, M., & BAGHERI, ALI. (2009). EFFECT OF ORAL FEEDING OF ALLIUM ASCALONICUM L. ON THORACIC AORTA CONTRACTILE RESPONSE IN DIABETIC RATS. KOOMESH, 10(3 (31)), 213-218. SID. https://sid.ir/paper/37266/en

Vancouver: Copy

FALAHI FARAMARZ, ROUGHANI M., BAGHERI ALI. EFFECT OF ORAL FEEDING OF ALLIUM ASCALONICUM L. ON THORACIC AORTA CONTRACTILE RESPONSE IN DIABETIC RATS. KOOMESH[Internet]. 2009;10(3 (31)):213-218. Available from: https://sid.ir/paper/37266/en

IEEE: Copy

FARAMARZ FALAHI, M. ROUGHANI, and ALI BAGHERI, “EFFECT OF ORAL FEEDING OF ALLIUM ASCALONICUM L. ON THORACIC AORTA CONTRACTILE RESPONSE IN DIABETIC RATS,” KOOMESH, vol. 10, no. 3 (31), pp. 213–218, 2009, [Online]. Available: https://sid.ir/paper/37266/en

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