INVESTIGATION OF FREE AND DENDROSOMAL CURCUMIN EFFECTS ON APOPTOSIS INDUCTION IN STEM CELLS AND CANCER CELL LINES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RANJI NAJMEH; SADEGHIZADEH MAJID; PADEGANEH ABBAS

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Pathobiology Research Year:2011 | Volume:14 | Issue:2 Page(s): 37-49

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,211

Download:

Cites:

Information Journal Paper

Title

INVESTIGATION OF FREE AND DENDROSOMAL CURCUMIN EFFECTS ON APOPTOSIS INDUCTION IN STEM CELLS AND CANCER CELL LINES

Author(s)

RANJI NAJMEH | SADEGHIZADEH MAJID | PADEGANEH ABBAS | Issue Writer Certificate

Keywords

DENDROSOMEQ2

CURCUMINQ2

NANOCURCUMINQ2

AGS CELLSQ2

APOPTOSISQ2

Abstract

Objective: CURCUMIN, is the active component in turmeric (Curcuma long). This agent induces APOPTOSIS via inhibiting various signaling pathways. However, its poor aqueous solubility prevents its widespread application. In this study, DENDROSOMEs with water-solubility, nano-sized dimensions and nontoxic properties, was used for CURCUMIN delivery to cells.Materials & Methods: In the present study, the potential of DENDROSOMEs for use as a drug delivery system was assessed in AGS, HT3, 5637, hBMSC and U87 cell lines. In order to achieve optimal concentration of drug and the most suitable cell line, the effects of different concentrations of free and dendrosomal CURCUMIN was examined on the cell lines. Propidium iodide staining was used for determining APOPTOSIS induction and the expression of Bax gene was investigated by semi-Q RT-PCR.Results: Dendrosomal formulation significantly improved water solubility of highly hydrophobic CURCUMIN in AGS CELLS. Flow cytometry analysis indicated 48 percent of cells treated with dendrosomal CURCUMIN and 20 percent of cells treated with free CURCUMIN (at the optimal concentration of drug) underwent APOPTOSIS after 18h. Semi-Q RT-PCR results exhibited the increase of expression of Bax pro-apoptotic gene in cells treated with dendrosomal CURCUMIN.Conclusion: Dendrosomal formulation, compared to free CURCUMIN, enhanced CURCUMIN solubility and increased APOPTOSIS induction in treated cells. These data, together with the observation of a 50 % increase of Bax gene expression confirmed the apoptotic effects of dendrosomal formulation of CURCUMIN.

Cites

No record.

References

No record.

Cite

APA: Copy

RANJI, NAJMEH, SADEGHIZADEH, MAJID, & PADEGANEH, ABBAS. (2011). INVESTIGATION OF FREE AND DENDROSOMAL CURCUMIN EFFECTS ON APOPTOSIS INDUCTION IN STEM CELLS AND CANCER CELL LINES. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 14(2), 37-49. SID. https://sid.ir/paper/81319/en

Vancouver: Copy

RANJI NAJMEH, SADEGHIZADEH MAJID, PADEGANEH ABBAS. INVESTIGATION OF FREE AND DENDROSOMAL CURCUMIN EFFECTS ON APOPTOSIS INDUCTION IN STEM CELLS AND CANCER CELL LINES. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2011;14(2):37-49. Available from: https://sid.ir/paper/81319/en

IEEE: Copy

NAJMEH RANJI, MAJID SADEGHIZADEH, and ABBAS PADEGANEH, “INVESTIGATION OF FREE AND DENDROSOMAL CURCUMIN EFFECTS ON APOPTOSIS INDUCTION IN STEM CELLS AND CANCER CELL LINES,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 14, no. 2, pp. 37–49, 2011, [Online]. Available: https://sid.ir/paper/81319/en

Related Journal Papers