EXPRESSION LEVELS OF KEY COMPONENTS OF THE HEDGEHOG PATHWAY AND AN INVESTIGATION OF THE CORRELATION OF THIS PATHWAY WITH EXPRESSION LEVELS OF CLAUDIN-1 IN INVASIVE BREAST CARCINOMA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SALEHI MARZIEH; BABASHAH SADEGH; ZEINALI SIROUS

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Pathobiology Research Year:2016 | Volume:19 | Issue:1 Page(s): 45-57

Download Full-Text

Persian Verion

View:

1,271

Download:

Cites:

Information Journal Paper

Title

EXPRESSION LEVELS OF KEY COMPONENTS OF THE HEDGEHOG PATHWAY AND AN INVESTIGATION OF THE CORRELATION OF THIS PATHWAY WITH EXPRESSION LEVELS OF CLAUDIN-1 IN INVASIVE BREAST CARCINOMA

Author(s)

SALEHI MARZIEH | BABASHAH SADEGH | ZEINALI SIROUS | Issue Writer Certificate

Keywords

BREAST CANCERQ2

HEDGEHOG SIGNALING PATHWAYQ1

CLAUDIN-1Q1

PROGNOSISQ3

Abstract

Objective: BREAST CANCER is considered a heterogeneous disease, characterized by different biological and phenotypic features which make its diagnosis and treatment challenging.We have sought to investigate the expression levels of key components of the HEDGEHOG SIGNALING PATHWAY, correlation between the signal transducer Smo, and clinic opathologic features (lymph node metastasis and metastasis stage) in invasive breast carcinoma. Also, we examined the inverse correlation between expression levels of Smo and CLAUDIN-1 (an important gene involved in cell tight junctions).Methods: In this case-control study, we assessed 36 pairs of tumor and adjacent normal tissue specimens obtained from patients with invasive ductal breast carcinoma. The expression levels of key components of Hedgehog signaling (Smo, Gli1 and Ptch), CLAUDIN-1, E-cadherin, and MMP2 were measured by qRT-PCR. The correlations between Smo expression with some clinic opathologic parameters were also analyzed.Results: We found up-regulation of Hedgehog signaling in invasive breast carcinoma samples compared to normal adjacent tissues. Up regulation of the signal transducer Smo correlated with tumor stages and lymph node metastasis of the breast tumors. Interestingly, this correlation was affected by the expression of Her2. A significant correlation existed between expression levels of the signal transducer Smo and CLAUDIN-1, E-cadherin as an epithelial cell marker, and MMP2 as a metastasis-related gene in advanced metastatic tumor samples.Conclusion: Taken together, our study revealed a new layer of molecular complexity which should be considered in the management of patients with invasive breast carcinoma. The results suggested a key role for Hedgehog signaling in invasive breast carcinoma. In terms of the inverse correlation between expression levels of CLAUDIN-1 and Hedgehog signaling, CLAUDIN-1 could serve as a candidate gene in diagnostic studies. Thus, its clinical significance should be further clarified.

Cites

No record.

References