SURVEY OF PROTECTIVE EFFECT OF GHAZZAYAGHI (FALCARIA VULGRIS) EXTRACT AGAINST ETHANOL-INDUCED PEPTIC ULCER IN RAT

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KHAZAEI M.; SALEHI H.; GHORBANI R.

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Journal: Anatomical Sciences Journal Year:2005 | Volume:2 | Issue:4 Page(s): 75-81

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Title

SURVEY OF PROTECTIVE EFFECT OF GHAZZAYAGHI (FALCARIA VULGRIS) EXTRACT AGAINST ETHANOL-INDUCED PEPTIC ULCER IN RAT

Author(s)

KHAZAEI M. | SALEHI H. | GHORBANI R. | Issue Writer Certificate

Keywords

GASTRIC ULCERQ4

FALCARIA VULGARISQ3

PROTECTIVE EFFECTQ4

ULCER INDEXQ4

Abstract

Purpose: Survey of PROTECTIVE EFFECTs of Ghazzayaghi (Falcaria vulgaris) extract against ethanol-induced peptic ulcer in rat.Materials and Methods: Thirty-five young male rats (NMRI); 200-250gr weight divided in to five groups (7 Rats/group), the groups were treated with: distilled water 10kg in Control negative group, 50mg/kg ranitidine in control positives group, and three case groups were treated with 50, 100, 150-mg/kg extract by gavages, all groups were treated with 50% ethanol (10 mg/kg), and after one hour, all rat were killed and dissected. The stomach cut in greater curvatures and ULCER INDEX was defined. Then, the stomachs were fixed and after tissue processing, 5-6, mm sections prepared for H.E staining and histological study and microscopic ULCER INDEX.Results: 70% ethanol extracts of Gazzayaghi with 50,100mg/kg body weight, significantly (P<0.05) decreased stomach ULCER INDEX, and curative ratio for 50,100,150mg/kg were 55.9%, 76.9% and 80.25% respectively. Microscopic ULCER INDEX with this three doses were reduced significantly (P<0.05) and curative ratio were 53.52%, 69.48% and 83.82% respectively.Conclusion: The plant extracts have effective PROTECTIVE EFFECT against GASTRIC ULCER induced by ethanol.

Cites

WOUND HEALING EFFECT OF FALCARIA VULGARIS' LEAVES ON ASPIRIN INDUCED GASTRIC ULCER IN RATS

References

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APA: Copy

KHAZAEI, M., SALEHI, H., & GHORBANI, R.. (2005). SURVEY OF PROTECTIVE EFFECT OF GHAZZAYAGHI (FALCARIA VULGRIS) EXTRACT AGAINST ETHANOL-INDUCED PEPTIC ULCER IN RAT. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 2(4), 75-81. SID. https://sid.ir/paper/81449/en

Vancouver: Copy

KHAZAEI M., SALEHI H., GHORBANI R.. SURVEY OF PROTECTIVE EFFECT OF GHAZZAYAGHI (FALCARIA VULGRIS) EXTRACT AGAINST ETHANOL-INDUCED PEPTIC ULCER IN RAT. JOURNAL OF IRANIAN ANATOMICAL SCIENCES[Internet]. 2005;2(4):75-81. Available from: https://sid.ir/paper/81449/en

IEEE: Copy

M. KHAZAEI, H. SALEHI, and R. GHORBANI, “SURVEY OF PROTECTIVE EFFECT OF GHAZZAYAGHI (FALCARIA VULGRIS) EXTRACT AGAINST ETHANOL-INDUCED PEPTIC ULCER IN RAT,” JOURNAL OF IRANIAN ANATOMICAL SCIENCES, vol. 2, no. 4, pp. 75–81, 2005, [Online]. Available: https://sid.ir/paper/81449/en

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