EFFECT OF A PERIOD OF SWIMMING EXERCISE ON SIRT1 AND FOXO3A GENES EXPRESSION IN LUNG TISSUE OF WISTAR RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHALESI MARYAM; MIRDAR SHADMEHR; SAMADI ALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Sabzevar University of Medical Sciences Year:2018 | Volume:25 | Issue:2 Page(s): 73-79

Download Full-Text

Persian Verion

View:

1,051

Download:

Cites:

Information Journal Paper

Title

EFFECT OF A PERIOD OF SWIMMING EXERCISE ON SIRT1 AND FOXO3A GENES EXPRESSION IN LUNG TISSUE OF WISTAR RATS

Author(s)

KHALESI MARYAM | MIRDAR SHADMEHR | SAMADI ALI | Issue Writer Certificate

Keywords

LUNG TISSUEQ2

OXIDATIVE STRESSQ1

SWIMMING EXERCISEQ1

Abstract

Physical activity and exercise along with nutrition and hygiene are major factors in prevention of diseases. Due to increase in pulmonary disease prevalence in recent decades and the role of OXIDATIVE STRESS in the pathogenesis of these diseases, the purpose of this study was to determine the effect of a period SWIMMING EXERCISE on Sirtuin 1 (Sirt1) and Forkhead box O3 (FoxO3a) genes expression in LUNG TISSUE of wistar rats.Materials and Methods: Twenty wistar rats with the weight of 102±23 g randomly divided into two groups: exercise (n=10) and control (n=10). The exercise protocol included three months of SWIMMING EXERCISE (5 times per week) which begun from 25 min in the first week (4 lit per min) and reached to 60 min (10 lit per min) in the final week. Real time- PCR method was used to assess the genes expression of Sirt1 and FoxO3a in LUNG TISSUE. Kolmogorov-Smirnov test was used to test the normality and Independent t test was used to compare the group (a<0.05).Results: Results showed that after3 month of SWIMMING EXERCISE gene expression of Sirt1 in lung was increased significantly (p=0.001) but no significant difference was observed in gene expression of FoxO3a between control and exercise group (p=0.09).Conclusion: Considering the role of Sirt1 in the cell stress resistance and its role in deoxyribonucleic acid repair, increased expression of Sirt1 may lead to cell resistance against the damaging factors and reduce the probability of pulmonary disorders.

Cites

No record.

References

No record.

Cite

APA: Copy

KHALESI, MARYAM, MIRDAR, SHADMEHR, & SAMADI, ALI. (2018). EFFECT OF A PERIOD OF SWIMMING EXERCISE ON SIRT1 AND FOXO₃A GENES EXPRESSION IN LUNG TISSUE OF WISTAR RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 25(2 ), 73-79. SID. https://sid.ir/paper/81779/en

Vancouver: Copy

KHALESI MARYAM, MIRDAR SHADMEHR, SAMADI ALI. EFFECT OF A PERIOD OF SWIMMING EXERCISE ON SIRT1 AND FOXO₃A GENES EXPRESSION IN LUNG TISSUE OF WISTAR RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;25(2 ):73-79. Available from: https://sid.ir/paper/81779/en

IEEE: Copy

MARYAM KHALESI, SHADMEHR MIRDAR, and ALI SAMADI, “EFFECT OF A PERIOD OF SWIMMING EXERCISE ON SIRT1 AND FOXO₃A GENES EXPRESSION IN LUNG TISSUE OF WISTAR RATS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 2 , pp. 73–79, 2018, [Online]. Available: https://sid.ir/paper/81779/en

Related Journal Papers