THE EFFECT OF EIGHT WEEKS OF INTERVAL TRAINING ON GENE EXPRESSION OF RYANODINE RECEPTORS' CALCIUM CHANNELS AND CALCIUM PUMP IN ISCHEMIC RATS

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SAZVAR AKBAR; MEHRIALVAR YAGHOB; GHARDASHI AFOUSI ALIREZA; NAZARI MOHAMMAD HOSSEIN

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Journal: Journal of Sabzevar University of Medical Sciences Year:2018 | Volume:25 | Issue:2 Page(s): 89-98

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Title

THE EFFECT OF EIGHT WEEKS OF INTERVAL TRAINING ON GENE EXPRESSION OF RYANODINE RECEPTORS' CALCIUM CHANNELS AND CALCIUM PUMP IN ISCHEMIC RATS

Author(s)

SAZVAR AKBAR | MEHRIALVAR YAGHOB | GHARDASHI AFOUSI ALIREZA | NAZARI MOHAMMAD HOSSEIN | Issue Writer Certificate

Keywords

MYOCARDIAL INFARCTIONQ3

RYANODINE RECEPTORS'Q1

INTENSE INTERVAL TRAININGQ1

SARCOPLASMIC NETWORKQ1

Abstract

Introduction: This study aimed to investigate the effect of eight weeks of interval training on gene expression of RYANODINE RECEPTORS' calcium channels and calcium pump in ischemic rats.Materials and Methods: 28 Wistar male rats (200-250 g) were used in this study. They were randomly divided into 4 groups: Sham, Ischemia, Exercise, and Exercise-ischemia. MYOCARDIAL INFARCTION (MI) was done by closing the left descending coronary artery (LAD) for 30 minutes. Exercise program on treadmill was for 8 weeks, 3 days a week for 40 minutes. The rats were anesthetized and the heart tissue was isolated 48 hours after the last training session and injections. Sarco-endoplasmic reticulum Ca2+-ATPases (SERCA2a) and RYANODINE RECEPTORS' (RyR2) gene expression was measured for heart tissue cells.Findings: The results showed that SERCA2a gene expression level was increased in both groups of exercise and exercise-ischemia (p=0.001) and this increase was significantly higher in exercise-ischemia group (p=0.001). Also, the results showed that 8 weeks of interval training significantly increased RyR2 gene expression level in two groups of exercise- ischemia and exercise. But a significant decrease was observed in RyR2 gene expression level in ischemia group.Conclusion The results of this study show that a regular interval training program eliminates abnormal contractions associated with cardiomyopathy due to myocardial ischemia and rehabilitates cardiac muscle calcium control and increases mainly the contraction strength by the increase of left ventricle mass.

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APA: Copy

SAZVAR, AKBAR, MEHRIALVAR, YAGHOB, GHARDASHI AFOUSI, ALIREZA, & NAZARI, MOHAMMAD HOSSEIN. (2018). THE EFFECT OF EIGHT WEEKS OF INTERVAL TRAINING ON GENE EXPRESSION OF RYANODINE RECEPTORS' CALCIUM CHANNELS AND CALCIUM PUMP IN ISCHEMIC RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 25(2 ), 89-98. SID. https://sid.ir/paper/81783/en

Vancouver: Copy

SAZVAR AKBAR, MEHRIALVAR YAGHOB, GHARDASHI AFOUSI ALIREZA, NAZARI MOHAMMAD HOSSEIN. THE EFFECT OF EIGHT WEEKS OF INTERVAL TRAINING ON GENE EXPRESSION OF RYANODINE RECEPTORS' CALCIUM CHANNELS AND CALCIUM PUMP IN ISCHEMIC RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;25(2 ):89-98. Available from: https://sid.ir/paper/81783/en

IEEE: Copy

AKBAR SAZVAR, YAGHOB MEHRIALVAR, ALIREZA GHARDASHI AFOUSI, and MOHAMMAD HOSSEIN NAZARI, “THE EFFECT OF EIGHT WEEKS OF INTERVAL TRAINING ON GENE EXPRESSION OF RYANODINE RECEPTORS' CALCIUM CHANNELS AND CALCIUM PUMP IN ISCHEMIC RATS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 2 , pp. 89–98, 2018, [Online]. Available: https://sid.ir/paper/81783/en

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